Gene Page - CG Number : CG11136

Gene Summary - CG11136:

CG11136: The gene Leucine-rich tendon-specific protein is referred to in FlyBase by the symbol Dmel\Lrt (CG11136, FBgn0034540). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of muscle cell chemotaxis toward tendon cell; Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell. 9 alleles are reported. The phenotypes of these alleles are annotated with: A1-7 ventral oblique muscle 4; A1-7 ventral acute muscle 3; embryonic/larval somatic muscle; ventral longitudinal muscle. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine-rich flanking region, C-terminal; Leucine-rich repeat; Leucine-rich repeat, typical subtype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis.

Gene summary for CG11136 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG11136:

CG11136 is not perturbed in primary screen.
CG11136 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG11136.

Cell Count:

CG_Number	Category	R1	R2	R3
CG11136	Primary screen	603	983	565

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG11136:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
20	1	248	-0.433539529	-0.902911954	-0.890345893	0.273501434	0.260368477	0.134625733	-0.364583815	0.11382523	-0.086537208	-0.436171928	-0.502648218	0.448284712	-0.621384478	-0.203698637	0.607786757	0.500005948	0.407466301	-0.746846347	-0.267184681	0.335829461	-0.722803792	0.882272492	-0.128164838
20	2	38	-0.221302843	0.251984442	0.089303936	-0.004291842	2.682496614	1.839750133	1.176151191	2.11154648	2.59662587	0.731303999	0.497702599	-0.427962519	5.512381217	3.234916026	3.608977114	1.30926241	-0.115193819	-0.14325554	-1.10839532	1.913192028	1.609621416	10.03160724	4.465237703
20	3	188	-0.450436453	0.733340172	0.802224116	-0.337396302	0.608470902	1.665203498	0.425039742	1.88325636	0.406425774	-0.25248681	-0.863076469	0.863495606	-0.017581066	1.393012848	-0.459652973	0.746633671	-0.543904558	-0.288813835	-1.132121467	0.457589937	0.992928256	0.222236905	-0.478060233

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG11136 is not tested in classification assay

Integrated Annotations for CG11136 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell	GO:2001283	inferred from genetic interaction with robo negative regulation of muscle cell chemotaxis toward tendon cell

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
muscle tendon junction	GO:0005927	inferred from direct assay plasma membrane

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
protein binding	GO:0005515	inferred from physical interaction with robo

Other annotations

Database	Link
FlyBase	Click here to see CG11136 in FlyBase
FLIGHT	Click here to see CG11136 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG11136 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG11136
Entrez Gene	Entrez Gene page for CG11136
Uniprot	Uniprot page for CG11136

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)