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Gene Page - CG Number : CG11144
Gene Summary - CG11144:

CG11144: The gene metabotropic glutamate receptor is referred to in FlyBase by the symbol Dmel\mGluRA (CG11144, FBgn0019985). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cholesterol binding; glutamate binding. There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission, glutamatergic; neuromuscular junction development. 13 alleles are reported. The phenotypes of these alleles are annotated with: bouton; type I bouton. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Extracellular ligand-binding receptor; GPCR, family 3; GPCR, family 3, C-terminal; GPCR, family 3, conserved site; GPCR, family 3, metabotropic glutamate receptor; GPCR, family 3, nine cysteines domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period.

Gene summary for CG11144 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11144:CG11144 is not perturbed in primary screen.
CG11144 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11144.
Cell Count:
CG_NumberCategoryR1R2R3
CG11144Primary screen639638622
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11144:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
201257-0.1323465290.0743928750.688826665-0.3544066430.001915310.8813999190.8042993130.9928617810.128722888-0.576989039-0.0674273131.7119257890.320676897-0.347783941.8749087880.723815895-0.099198016-0.5006823260.0507498140.778676228-0.435119229-0.708883155-0.70609374
20259-0.46386151-0.43418288-0.208922197-0.5911967960.8514900432.1012189031.8082015682.4986459361.877501501-0.280673657-1.059147662-0.1882291690.580426161.3325288281.0186859560.411839678-0.505341108-0.9885263580.6344219961.818109171-0.3543638720.8744174230.784679138
203209-0.535646997-0.448369372-0.3338731730.1450346921.3163345840.066181007-0.5337452010.1468251250.5126173150.647289241-0.570524448-0.04837339-0.534515936-0.5897072990.4163498590.653472811-0.1568002190.684382347-0.83703080.246796664-0.7747400460.005567276-0.315992228
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11144 is not tested in classification assay
Integrated Annotations for CG11144 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of synaptic transmission, glutamatergicGO:0051966inferred from mutant phenotype
neuromuscular junction development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886non-traceable author statement
integral to plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
G-protein coupled receptor activityGO:0004930inferred from sequence or structural similarity
glutamate binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11144 in FlyBase
FLIGHTClick here to see CG11144 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11144 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11144
Entrez GeneEntrez Gene page for CG11144
UniprotUniprot page for CG11144

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)