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Gene Page - CG Number : CG11186
Gene Summary - CG11186:

CG11186: The gene twin of eyeless is referred to in FlyBase by the symbol Dmel\toy (CG11186, FBgn0019650). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: brain morphogenesis; positive regulation of gene expression; eye-antennal disc development; positive regulation of transcription from RNA polymerase II promoter; ocellus development; mushroom body development. 23 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system subdivision; organ system; adult segment; multicellular structure; adult; imaginal precursor; embryonic/larval imaginal precursor; thoracic segment; non-connected developing system; embryonic brain; region of integument. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like; Paired domain; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period.

Gene summary for CG11186 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11186:CG11186 is not perturbed in primary screen.
CG11186 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11186.
Cell Count:
CG_NumberCategoryR1R2R3
CG11186Primary screen320591557
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11186:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2012781.6640480560.3238591280.689170723-0.463687862-1.591479656-5.714749896-3.426721821-4.606632962-1.616151017-0.637195831-0.3767434710.37759671-0.473838029-0.4116659890.322397313-1.2517577371.4015053280.2933146111.595806472-2.7903322350.9330448410.427833950.050849192
20280.117864203-0.109308132-0.1887985850.4300418850.5901758411.3803989171.4833623081.6556322660.1474212090.340035516-0.4269470840.65332359-0.608377506-0.237173390.46255422-0.131007418-0.895177936-0.1322694550.1208531030.335505756-0.0571517222.4615839770.682994297
203158-0.555997769-0.383503581-0.082232907-0.7530613130.480267190.190444869-0.2101606480.5536746430.2260862920.0074479731.047976050.61579255-0.791065141-0.551173050.4427095490.9231220611.1102057980.654914731.5353394390.1453522140.0324180120.973038832-0.041008959
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11186 is not tested in classification assay
Integrated Annotations for CG11186 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
eye-antennal disc developmentGO:0035214inferred from mutant phenotype
compound eye development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634non-traceable author statement
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700non-traceable author statement
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11186 in FlyBase
FLIGHTClick here to see CG11186 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11186 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11186
Entrez GeneEntrez Gene page for CG11186
UniprotUniprot page for CG11186

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)