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Gene Page - CG Number : CG1119
Gene Summary - CG1119:

CG1119: The gene Germ line transcription factor 1 is referred to in FlyBase by the symbol Dmel\Gnf1 (CG1119, FBgn0004913). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: lateral inhibition; neurogenesis. 7 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; chaeta; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, core; BRCT domain; DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal; DNA replication factor C, large subunit; DNA replication factor RFC1, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG1119 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1119:CG1119 is perturbed in following parameters in primary screen: Tint4 Tmph1 Tmph2
CG1119 is not tested in classification assay (fluid).
CG1119 is perturbed in following parameters in classification assay (transferrin): CellSize+(tfr) Fint1+ Fmph2+ Fmph3+ Fnum+ NuCirc-(tfr) NuFluct+(tfr) NuSize+(tfr) Rto1+(tfr) Tclc+ Tint1+ Tint2+ Tint4- Tnum+
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1119.
Cell Count:
CG_NumberCategoryR1R2R3
CG1119Primary screen528428307
CG1119Secondary assay855934962
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1119:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1119Slide2F0.0001.4301.3991.381
CG1119Slide2O0.1491.0411.0601.179
CG1119Slide2T0.2901.0741.0371.129
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1119 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
DNA replicationGO:0006260non-traceable author statement
neurogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
DNA replication factor C complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677inferred from direct assay
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1119 in FlyBase
FLIGHTClick here to see CG1119 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1119 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1119
Entrez GeneEntrez Gene page for CG1119
UniprotUniprot page for CG1119

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)