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Gene Page - CG Number : CG11228
Gene Summary - CG11228:

CG11228: The gene hippo is referred to in FlyBase by the symbol Dmel\hpo (CG11228, FBgn0261456). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein serine/threonine kinase activity; protein homodimerization activity; kinase activity. There is experimental evidence for 16 unique biological process terms, many of which group under: biological regulation; regulation of apoptotic process; cell proliferation; sensory organ development; programmed cell death; cell death; macromolecule modification; response to ionizing radiation; growth; morphogenesis of an epithelial sheet. 64 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; external compound sense organ; imaginal precursor; adult segment; thoracic segment; organ system; adult; peripheral nervous system; embryonic/larval imaginal precursor; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SARAH; SARAH domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG11228 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11228:CG11228 is perturbed in following parameters in primary screen: Tint3 Tmph2
CG11228 is not tested in classification assay (fluid).
CG11228 is not perturbed in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11228.
Cell Count:
CG11228Primary screen369487367
CG11228Secondary assay10522401318
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11228:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11228 :Gene Ontology Annoations: Biological Process
Gene Ontology Annoations: Cellular Component
Gene Ontology Annoations: Molecular Function
Other annotations
FlyBaseClick here to see CG11228 in FlyBase
FLIGHTClick here to see CG11228 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11228 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11228
Entrez GeneEntrez Gene page for CG11228
UniprotUniprot page for CG11228

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)