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Gene Page - CG Number : CG11257
Gene Summary - CG11257:

CG11257: This gene is referred to in FlyBase by the symbol Dmel\CG11257 (FBgn0034442). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: heme binding; oxidoreductase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome b5; Cytochrome b5, heme-binding site; Ferredoxin reductase-type FAD-binding domain; HSP20-like chaperone; NADH:cytochrome b5 reductase (CBR); Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase, FAD-binding domain; Riboflavin synthase-like beta-barrel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11257 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11257:CG11257 is not perturbed in primary screen.
CG11257 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint2- LP_Fint3- LP_Fmph1- LP_Fmph2- LP_Fmph3- LP_Fnum- Rto1+ Rto2+ SP_Fclc- SP_Fint3- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG11257 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11257.
Cell Count:
CG11257Primary screen835679171
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11257:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11257 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
oxidation-reduction processGO:0055114inferred from electronic annotation with InterPro:IPR001433, InterPro:IPR001834, InterPro:IPR017927, InterPro:IPR017938
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
oxidoreductase activityGO:0016491inferred from electronic annotation with InterPro:IPR001433, InterPro:IPR001834, InterPro:IPR017927, InterPro:IPR017938
heme binding
Other annotations
FlyBaseClick here to see CG11257 in FlyBase
FLIGHTClick here to see CG11257 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11257 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11257
Entrez GeneEntrez Gene page for CG11257
UniprotUniprot page for CG11257

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)