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Gene Page - CG Number : CG11268
Gene Summary - CG11268:

CG11268: The gene isoprenylcysteine carboxylmethyltransferase is referred to in FlyBase by the symbol Dmel\ste14 (CG11268, FBgn0036336). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: C-terminal protein methylation. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Isoprenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-methyltransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG11268 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11268:CG11268 is not perturbed in primary screen.
CG11268 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11268.
Cell Count:
CG_NumberCategoryR1R2R3
CG11268Primary screen724604599
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11268:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211190.115662526-0.617264637-0.03385061-0.7577963610.21761448-1.074334204-0.584980914-0.486821256-0.2464807121.1078598310.4266722740.1549244170.661939101-0.2615615191.8143640660.5997889990.3772917140.7893160580.2111594920.4216774592.2443849390.812727366-0.309482033
212177-0.4273256150.3418707520.44063221-0.4902736230.9791163871.1758449020.3992885751.294064571.186699986-0.19668639-1.020903475-0.40986873-0.233886282-0.9852131442.9853497610.5132756610.281513611-0.5606344950.0653875870.890396412-0.6147368710.4479865870.811597606
2131470.6047966460.147971729-0.4949371070.5465491761.0598923291.3401928340.5599299951.4567604071.3320844580.213364088-0.2106265340.2243195930.28561537-0.6265354920.1922105841.587163276-0.164757772-0.4440755320.1245109141.0716145354.1352207866.3111142145.217635984
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11268 is not tested in classification assay
Integrated Annotations for CG11268 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
C-terminal protein methylationGO:0006481inferred from electronic annotation with InterPro:IPR007269
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to membraneGO:0016021inferred from electronic annotation with InterPro:IPR007269
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activityGO:0004671inferred from sequence or structural similarity with MGD:Icmt; MGI:MGI:1888594
Other annotations
DatabaseLink
FlyBaseClick here to see CG11268 in FlyBase
FLIGHTClick here to see CG11268 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11268 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11268
Entrez GeneEntrez Gene page for CG11268
UniprotUniprot page for CG11268

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)