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Gene Page - CG Number : CG11290
Gene Summary - CG11290:

CG11290: The gene enoki mushroom is referred to in FlyBase by the symbol Dmel\enok (CG11290, FBgn0034975). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: histone acetyltransferase activity. There is experimental evidence that it is involved in the biological process: dorsal/ventral axon guidance; neuroblast proliferation; mushroom body development; regulation of JAK-STAT cascade. 16 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Acyl-CoA N-acyltransferase; Histone H1/H5; MOZ/SAS-like protein; Winged helix-turn-helix transcription repressor DNA-binding; Zinc finger, FYVE/PHD-type; Zinc finger, PHD-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in adult female stages.

Gene summary for CG11290 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11290:CG11290 is perturbed in following parameters in primary screen: Fclc Fint2 Fint3 Fmph1 Fmph2 Fmph3 NuCirc NuFluct NuSize Rto2 Rto3 Tclc Tint2 Tint3 Tint4 Tmph1 Tmph2 Tmph3 Tnum
CG11290 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc- LP_Fmph3- LP_Fnum- NuCellD+(fld) NuSize-(fld) Okt-(fld) SP_Fclc- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG11290 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint4- Tint1+ Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11290.
Cell Count:
CG_NumberCategoryR1R2R3
CG11290Primary screen1229447655
CG11290Secondary assay90512511213
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11290:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
21131-0.3237890484.6421181445.1278739930.2673285983.1316620819.79416013711.206742868.04228714412.7188036711.8149246813.81736541-0.2766113387.83515478.2645404477.3740872993.03344942418.325624115.4372021324.7441619415.281477773.6424346616.0189543478.396760039
212195-0.2858340723.38560935.832815757-0.7082058511.7734010525.6349040835.4173359015.69728879611.217283239.5389827429.6431312072.18613466910.5647786410.753408160.6533490713.39630719219.1924194114.2343207628.478397348.713618581-0.0370337686.7609258316.433291285
2131050.069511312.2448506482.8311406981.5627157862.3177010525.9051729076.6295438036.9979105417.5120503653.7130241316.6566961462.1818820490.8029201031.6100346382.489225381.83046963313.2308654716.362734919.302948239.7022340230.4591653227.0798910467.26630662
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11290Slide10C0.5001.1250.9100.555
CG11290Slide10O0.0750.9270.7190.718
CG11290Slide10P0.1060.8980.6360.420
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11290Slide2F0.4801.0110.9110.996
CG11290Slide2O0.5160.9950.9790.967
CG11290Slide2T0.4601.1450.8100.572
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11290 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mushroom body developmentGO:0016319inferred from mutant phenotype
neuroblast proliferation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
histone acetyltransferase complexGO:0000123inferred from sequence or structural similarity with SGD_LOCUS:ESA1; SGD:S0005770
nucleosome
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
histone acetyltransferase activityGO:0004402inferred from sequence or structural similarity with SGD_LOCUS:ESA1; SGD:S0005770
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11290 in FlyBase
FLIGHTClick here to see CG11290 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11290 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11290
Entrez GeneEntrez Gene page for CG11290
UniprotUniprot page for CG11290

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)