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Gene Page - CG Number : CG11299
Gene Summary - CG11299:

CG11299: The gene Sestrin is referred to in FlyBase by the symbol Dmel\Sesn (CG11299, FBgn0034897). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; regulation of reactive oxygen species metabolic process; mitochondrion degradation; multicellular organismal aging; negative regulation of cell growth. 12 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; myofibril; actomyosin; wing blade; sarcomere; mitochondrion; M band. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: PA26 p53-induced protein (sestrin). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period.

Gene summary for CG11299 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11299:CG11299 is not perturbed in primary screen.
CG11299 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11299.
Cell Count:
CG_NumberCategoryR1R2R3
CG11299Primary screen419698259
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11299:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211352.2299830550.523265289-0.212981774-0.347152714-0.919969221-6.801809759-0.983210643-5.713157687-3.00284353-0.1542179931.2069760640.633804371-0.7575734340.4459232460.9156037120.042920008-0.282130448-0.038497222-0.776441977-1.8556067250.895501279-0.775168846-0.485602882
2121911.6190435530.6165374070.5290099471.0875044530.311291413-1.0762494110.988809368-0.763664366-0.11940032-0.681389723-0.120886391-0.2662914030.5085977270.0868607782.7642261771.95309548-0.9734553740.463168254-0.441965094-0.3810450072.1962251790.1469687670.705523865
2131011.0389983180.907562594-0.4125709640.896439665-0.933176339-2.372483333-1.809221635-2.054895565-0.8804364240.3805749520.205695843-0.3678501560.9046031521.286783554-0.591611803-0.797291154-0.7200982490.004573119-0.634759769-1.8274941810.5582067156.4931816045.049423515
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11299 is not tested in classification assay
Integrated Annotations for CG11299 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
inter-male aggressive behaviorGO:0002121inferred from mutant phenotype
negative regulation of cell growth
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634non-traceable author statement
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
-
Other annotations
DatabaseLink
FlyBaseClick here to see CG11299 in FlyBase
FLIGHTClick here to see CG11299 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11299 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11299
Entrez GeneEntrez Gene page for CG11299
UniprotUniprot page for CG11299

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)