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Gene Page - CG Number : CG1130
Gene Summary - CG1130:

CG1130: The gene scratch is referred to in FlyBase by the symbol Dmel\scrt (CG1130, FBgn0004880). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter. 13 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; eye; neuron; macrochaeta; anterior crossvein; photoreceptor cell; eye photoreceptor cell; wing; microchaeta; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages.

Gene summary for CG1130 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1130:CG1130 is perturbed in following parameters in primary screen: Fclc Fint3 Tint1 Tint2 Tint3 Tmph1 Tmph2 Tmph3
CG1130 is perturbed in following parameters in classification assay (fluid): LP_Fint1+ LP_Fint2+ LP_Fint3+ Rto1- Rto3- SP_Fint2+ SP_Fint3+
CG1130 is perturbed in following parameters in classification assay (transferrin): CellSize+(tfr) NuCirc-(tfr) NuFluct+(tfr) Okt+(tfr) Tmph2-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1130.
Cell Count:
CG_NumberCategoryR1R2R3
CG1130Primary screen96146138
CG1130Secondary assay906685411
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1130:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1130Slide20C0.0011.3181.2771.401
CG1130Slide20O0.7300.9221.0831.124
CG1130Slide20P0.0251.0641.1271.113
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1130Slide2F0.2400.8960.6400.970
CG1130Slide2O0.0041.3351.2141.242
CG1130Slide2T0.5160.7980.9661.043
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1130 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dendrite morphogenesisGO:0048813inferred from mutant phenotype
regulation of transcription, DNA-dependent
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with UniProtKB:P18747
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with UniProtKB:P18747
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG1130 in FlyBase
FLIGHTClick here to see CG1130 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1130 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1130
Entrez GeneEntrez Gene page for CG1130
UniprotUniprot page for CG1130

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)