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Gene Page - CG Number : CG1133
Gene Summary - CG1133:

CG1133: The gene odd paired is referred to in FlyBase by the symbol Dmel\opa (CG1133, FBgn0003002). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: decapentaplegic signaling pathway; eye-antennal disc morphogenesis; germ cell migration; midgut development. 43 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: multicellular structure; anatomical structure; organ system; acellular anatomical structure; late extended germ band embryo; imaginal precursor; extended germ band embryo; embryonic gnathal segment; non-connected developing system; larval head segment; heart primordium; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG1133 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1133:CG1133 is perturbed in following parameters in primary screen: Fclc Tclc
CG1133 is perturbed in following parameters in classification assay (fluid): LP_Fclc+ NuSize+(fld) Okt-(fld)
CG1133 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1133.
Cell Count:
CG_NumberCategoryR1R2R3
CG1133Primary screen774614314
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1133:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1133Slide20C0.9510.8300.8881.321
CG1133Slide20O0.0420.6540.7910.825
CG1133Slide20P0.3120.9971.0471.177
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG1133 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
decapentaplegic signaling pathwayGO:0008101inferred from mutant phenotype
eye-antennal disc morphogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with UniProtKB:O95409
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with ci AND inferred from sequence or structural similarity with HGNC_gene:GLI3; HGNC:4319; OMIM:165240
sequence-specific DNA binding transcription factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1133 in FlyBase
FLIGHTClick here to see CG1133 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1133 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1133
Entrez GeneEntrez Gene page for CG1133
UniprotUniprot page for CG1133

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)