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Gene Page - CG Number : CG11331
Gene Summary - CG11331:

CG11331: The gene Serpin 27A is referred to in FlyBase by the symbol Dmel\Spn27A (CG11331, FBgn0028990). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: enzyme inhibitor activity; serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: defense response to fungus; defense response to insect; negative regulation of proteolysis; melanization defense response; Toll signaling pathway; negative regulation of melanization defense response; response to wounding; dorsal/ventral axis specification; melanotic encapsulation of foreign target; behavioral response to ethanol. 16 alleles are reported. The phenotypes of these alleles are annotated with: embryonic epidermis; trachea; wing; embryonic dorsal epidermis. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protease inhibitor I4, serpin, conserved site; Serpin domain; Serpin family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout the pupal period.

Gene summary for CG11331 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11331:CG11331 is not perturbed in primary screen.
CG11331 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11331.
Cell Count:
CG_NumberCategoryR1R2R3
CG11331Primary screen131472505
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11331:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
21152-1.453931563-1.621834519-0.222730244-1.625474293-2.521399155-5.662851624-3.823521081-4.589121269-2.6951011291.7011418222.6569456760.073858890.1956413311.5678547880.762309978-1.9010404922.9957268944.8669125760.731636248-1.6135255720.6670162421.4170250571.039307333
2122041.143727985-0.015644639-0.080728522-0.524343852-0.148348442-1.133182325-0.175541039-1.5773867590.7201023370.485485462.124723446-0.2478319350.729955675-0.0850022910.459323829-0.3343292750.5256544492.6182904710.3728707360.3499047960.1009547094.5593696720.025392144
2131141.2681090830.5525355041.4204518490.730143553-1.005170048-0.2613261940.431633695-0.939760296-1.261807375-0.0851239820.393517964-0.643400385-0.211837189-0.507200071-0.231548280.4892885010.8574295460.748626160.7678636-0.47164878-0.1029385770.636986722-0.12526239
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11331 is not tested in classification assay
Integrated Annotations for CG11331 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
negative regulation of melanization defense responseGO:0035009inferred from mutant phenotype
Toll signaling pathway
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
extracellular regionGO:0005576inferred from direct assay
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
serine-type endopeptidase inhibitor activityGO:0004867non-traceable author statement
enzyme inhibitor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11331 in FlyBase
FLIGHTClick here to see CG11331 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11331 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11331
Entrez GeneEntrez Gene page for CG11331
UniprotUniprot page for CG11331

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)