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Gene Page - CG Number : CG11354
Gene Summary - CG11354:

CG11354: This gene is referred to in FlyBase by the symbol Dmel\Lim1 (CG11354, FBgn0026411). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: leg disc proximal/distal pattern formation; positive regulation of transcription, DNA-dependent; imaginal disc-derived leg morphogenesis; negative regulation of transcription, DNA-dependent. 27 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; adult segment; appendage segment; organ system; thoracic segment; adult uniglomerular antennal lobe projection neuron vPN; metatarsus; unguis; mesothoracic preepisternum; antennal lobe projection neuron vPN. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early pupal stages.

Gene summary for CG11354 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11354:CG11354 is not perturbed in primary screen.
CG11354 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11354.
Cell Count:
CG_NumberCategoryR1R2R3
CG11354Primary screen577296306
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11354:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
21161-0.1839952631.6132155252.036034150.878175802-0.1921592460.9479129722.360559170.7230809930.93457012-0.207613188-0.161768977-0.6841465050.8912260750.863336928-0.3778057220.541309072-0.671518899-0.765316344-0.1948599781.1948096630.3859909220.41058569-0.15693552
212225-0.2123876780.072335007-0.246562135-0.612630046-0.545609623-1.796882935-1.360866433-2.002697567-3.666036181-1.081977438-1.1233943520.403041216-0.421540201-1.113652351.772567342-1.1118197021.898446678-1.6029126120.51640726-2.87452708-0.331882326-0.620239962-1.075030617
21375-0.598785536-0.5308891370.104924319-0.539874427-1.686424358-3.678698654-2.348547901-3.846867418-4.663111234-1.127073179-0.048904842-0.096310021-0.6381166131.77771696-0.045283065-0.917747368-0.231722815-0.570503963-0.99810031-5.083284820.7241643192.0418624020.459063456
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11354 is not tested in classification assay
Integrated Annotations for CG11354 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
imaginal disc-derived leg morphogenesisGO:0007480inferred from mutant phenotype
leg disc proximal/distal pattern formation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with MGD:Lhx1; MGI:MGI:99783
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with EMBL:AY339649
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11354 in FlyBase
FLIGHTClick here to see CG11354 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11354 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11354
Entrez GeneEntrez Gene page for CG11354
UniprotUniprot page for CG11354

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)