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Gene Page - CG Number : CG11387
Gene Summary - CG11387:

CG11387: The gene cut is referred to in FlyBase by the symbol Dmel\ct (CG11387, FBgn0004198). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription regulatory region sequence-specific DNA binding. There is experimental evidence for 15 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; antennal development; appendage development; multicellular organism reproduction; gamete generation; neuron differentiation; ovarian follicle cell development; kidney epithelium development; regulation of RNA metabolic process; post-embryonic organ morphogenesis; open tracheal system development; cell cycle; sensory perception of sound; formation of a compartment boundary. 324 alleles are reported. The phenotypes of these alleles are annotated with 69 unique terms, many of which group under: organ system subdivision; adult segment; organ system; larval abdominal segment; spiracle; peripheral nervous system; integumentary specialisation; thoracic segment; external compound sense organ; adult antennal lobe. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain protein CUT; Homeodomain-like; Lambda repressor-like, DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages.

Gene summary for CG11387 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11387:CG11387 is perturbed in following parameters in primary screen: Fint2 Fint3
CG11387 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint1- LP_Fint1- LP_Fint2- LP_Fint2- LP_Fint3- LP_Fint3- LP_Fint4+ NuFluct+(fld) NuSize-(fld) Okt+(fld) Rto1+ Rto1+ Rto2+ Rto3+ SP_Fclc- SP_Fint1- SP_Fint2- SP_Fint2- SP_Fint3- SP_Fint3- SP_Fint4+ SP_Fmph1- SP_Fmph2+ SP_Fmph2- SP_Fmph3- SP_Fnum-
CG11387 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11387.
Cell Count:
CG_NumberCategoryR1R2R3
CG11387Primary screen367245114
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11387:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211731.4649475014.8033010145.42544362.2003656990.1994776442.6272466258.3299361162.9474761441.3851932040.027732461-0.153262815-0.8273488390.1019334220.440173882.6004925790.39653227-0.466541999-0.0861516-0.8286570623.2624232650.665394499-0.198219802-0.124624154
212213-0.625863560.534067040.8894394390.176408889-0.4540443710.171613041.6105910041.093464539-0.415772505-1.0635077540.633464331-0.09856307-1.541166589-0.332114878-0.365327527-0.588324224-1.119674624-1.257576181-1.3758326880.329034023-0.0989289961.308879501-0.034636187
213632.7538774364.8096520293.696827676-0.894710391-1.266251146-1.121550157-0.064135242-1.275230056-1.6356183680.657535135-0.542671137-0.971884621-1.133102018-1.077737744-0.835595468-1.4747229720.8154887870.208867073.788523112-0.613412751.515937858-0.765893685-0.0365768
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11387Slide14C0.0010.6230.5650.471
CG11387Slide14O0.7751.2741.0190.832
CG11387Slide14P0.0130.8090.7050.693
CG11387Slide4C0.0390.6270.4710.667
CG11387Slide4O0.0571.5241.2021.524
CG11387Slide4P0.0800.6720.4770.807
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11387 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dendrite morphogenesisGO:0048813inferred from mutant phenotype
Malpighian tubule morphogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677traceable author statement
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11387 in FlyBase
FLIGHTClick here to see CG11387 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11387 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11387
Entrez GeneEntrez Gene page for CG11387
UniprotUniprot page for CG11387

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)