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Gene Page - CG Number : CG1140
Gene Summary - CG1140:

CG1140: This gene is referred to in FlyBase by the symbol Dmel\CG1140 (FBgn0035298). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: 3-oxoacid CoA-transferase activity. Based on sequence similarity, it is predicted to be involved in the biological process: ketone body catabolic process. 9 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: 3-oxoacid CoA-transferase; 3-oxoacid CoA-transferase, subunit A; 3-oxoacid CoA-transferase, subunit B; Coenzyme A transferase active site; Coenzyme A transferase binding site; Coenzyme A transferase family I. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early larval stages.

Gene summary for CG1140 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1140:CG1140 is perturbed in following parameters in primary screen: Fmph2 Tclc Tint4 Tmph1 Tmph2 Tmph3
CG1140 is perturbed in following parameters in classification assay (fluid): LP_Fint3+
CG1140 is perturbed in following parameters in classification assay (transferrin): CellSize+(tfr) Fint1- Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint2- Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1140.
Cell Count:
CG_NumberCategoryR1R2R3
CG1140Primary screen388777335
CG1140Secondary assay564440844
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1140:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1140Slide26C0.0631.2061.2801.428
CG1140Slide26O0.6180.1581.1281.138
CG1140Slide26P0.7300.5071.0061.188
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1140Slide2F0.0720.8870.9650.864
CG1140Slide2O0.1551.5351.0961.232
CG1140Slide2T0.2860.9230.9870.714
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1140 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
ketone body catabolic processGO:0046952inferred from sequence or structural similarity with UniProtKB:P55809
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
mitochondrial matrixGO:0005759inferred from sequence or structural similarity with UniProtKB:P55809
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
3-oxoacid CoA-transferase activityGO:0008260inferred from sequence or structural similarity with UniProtKB:Q29551
3-oxoacid CoA-transferase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1140 in FlyBase
FLIGHTClick here to see CG1140 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1140 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1140
Entrez GeneEntrez Gene page for CG1140
UniprotUniprot page for CG1140

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)