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Gene Page - CG Number : CG11401
Gene Summary - CG11401:

CG11401: The gene thioredoxin reductase 2 is referred to in FlyBase by the symbol Dmel\Trxr-2 (CG11401, FBgn0037170). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: thioredoxin-disulfide reductase activity. Based on sequence similarity, it is predicted to be involved in the biological process: cell redox homeostasis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD/NAD-linked reductase, dimerisation; Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain; Pyridine nucleotide-disulphide oxidoreductase, class I, active site; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Thioredoxin/glutathione reductase selenoprotein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG11401 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11401:CG11401 is perturbed in following parameters in primary screen: Fmph2
CG11401 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc+ LP_Fint1+ LP_Fint2+ LP_Fint3+ Rto2- Rto3- SP_Fint1+ SP_Fint4- SP_Fmph1+ SP_Fmph2+ SP_Fmph3+ SP_Fnum+
CG11401 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11401.
Cell Count:
CG_NumberCategoryR1R2R3
CG11401Primary screen372286121
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11401:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211801.8641398950.8381588983.0244293360.0772270790.0297705756.0285339486.8429768533.1290711191.9820610070.3166934040.2155591940.7245463030.8444843372.1297914940.5567562840.1489313030.6414788090.0500932750.2017781332.7895230271.266797645.2597081154.338426929
212236-0.1652917080.1332068852.1490378890.611227408-0.6439531521.9452847763.2129925180.6610977271.373472171.1445795882.676454739-0.3674390490.4144666470.4945161240.07781808-0.1616738133.1058257375.2818179051.9471918682.453620269-0.5378645062.781340808-0.189358243
21386-0.026330788-0.404208261-0.1024764511.285641097-1.040563988-2.868935083-1.536081102-2.951372592-2.778728745-0.535161719-0.223239396-0.5289208370.1683432822.464285622-0.890973441-1.65818301-0.1150956860.0842721351.458204072-2.0314082470.299491457-0.1752808230.787710858
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11401Slide20C0.0351.1541.2761.384
CG11401Slide20O0.1971.0191.2841.171
CG11401Slide20P0.4280.9771.0541.136
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11401 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
cell redox homeostasisGO:0045454inferred from sequence or structural similarity with UniProtKB:P91938
oxidation-reduction process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
cytoplasmGO:0005737inferred from sequence or structural similarity with UniProtKB:P91938
mitochondrion
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
antioxidant activityGO:0016209inferred from sequence or structural similarity with UniProtKB:P91938
thioredoxin-disulfide reductase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11401 in FlyBase
FLIGHTClick here to see CG11401 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11401 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11401
Entrez GeneEntrez Gene page for CG11401
UniprotUniprot page for CG11401

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)