Gene Page - CG Number : CG11401

Gene Summary - CG11401:

CG11401: The gene thioredoxin reductase 2 is referred to in FlyBase by the symbol Dmel\Trxr-2 (CG11401, FBgn0037170). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: thioredoxin-disulfide reductase activity. Based on sequence similarity, it is predicted to be involved in the biological process: cell redox homeostasis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD/NAD-linked reductase, dimerisation; Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain; Pyridine nucleotide-disulphide oxidoreductase, class I, active site; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Thioredoxin/glutathione reductase selenoprotein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG11401 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG11401:

CG11401 is perturbed in following parameters in primary screen: Fmph2
CG11401 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fclc+ LP_Fint1+ LP_Fint2+ LP_Fint3+ Rto2- Rto3- SP_Fint1+ SP_Fint4- SP_Fmph1+ SP_Fmph2+ SP_Fmph3+ SP_Fnum+
CG11401 is not tested in classification assay (transferrin).

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG11401.

Cell Count:

CG_Number	Category	R1	R2	R3
CG11401	Primary screen	372	286	121

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG11401:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
21	1	80	1.864139895	0.838158898	3.024429336	0.077227079	0.029770575	6.028533948	6.842976853	3.129071119	1.982061007	0.316693404	0.215559194	0.724546303	0.844484337	2.129791494	0.556756284	0.148931303	0.641478809	0.050093275	0.201778133	2.789523027	1.26679764	5.259708115	4.338426929
21	2	236	-0.165291708	0.133206885	2.149037889	0.611227408	-0.643953152	1.945284776	3.212992518	0.661097727	1.37347217	1.144579588	2.676454739	-0.367439049	0.414466647	0.494516124	0.07781808	-0.161673813	3.105825737	5.281817905	1.947191868	2.453620269	-0.537864506	2.781340808	-0.189358243
21	3	86	-0.026330788	-0.404208261	-0.102476451	1.285641097	-1.040563988	-2.868935083	-1.536081102	-2.951372592	-2.778728745	-0.535161719	-0.223239396	-0.528920837	0.168343282	2.464285622	-0.890973441	-1.65818301	-0.115095686	0.084272135	1.458204072	-2.031408247	0.299491457	-0.175280823	0.787710858

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

Fluid:

CG_Number	Slide No.	ttest P-value	Ratio 1	Ratio 2	Ratio 3
CG11401	Slide20C	0.035	1.154	1.276	1.384
CG11401	Slide20O	0.197	1.019	1.284	1.171
CG11401	Slide20P	0.428	0.977	1.054	1.136

C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11401 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
cell redox homeostasis	GO:0045454	inferred from sequence or structural similarity with UniProtKB:P91938 oxidation-reduction process

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
cytoplasm	GO:0005737	inferred from sequence or structural similarity with UniProtKB:P91938 mitochondrion

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
antioxidant activity	GO:0016209	inferred from sequence or structural similarity with UniProtKB:P91938 thioredoxin-disulfide reductase activity

Other annotations

Database	Link
FlyBase	Click here to see CG11401 in FlyBase
FLIGHT	Click here to see CG11401 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG11401 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG11401
Entrez Gene	Entrez Gene page for CG11401
Uniprot	Uniprot page for CG11401

---

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)