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Gene Page - CG Number : CG11419
Gene Summary - CG11419:

CG11419: The gene Anaphase promoting complex subunit 10 is referred to in FlyBase by the symbol Dmel\Apc10 (CG11419, FBgn0034231). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mitotic anaphase-promoting complex activity. There is experimental evidence that it is involved in the biological process: mitosis; endomitotic cell cycle; neurogenesis. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Anaphase-promoting complex, subunit 10; Anaphase-promoting complex, subunit 10/DOC domain; Galactose-binding domain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.

Gene summary for CG11419 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11419:CG11419 is perturbed in following parameters in primary screen: Tint2
CG11419 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fclc- LP_Fint4+ LP_Fmph2- LP_Fmph3- LP_Fnum- NuCellD-(fld) Okt+(fld) Rto1+ Rto2+ Rto3+ SP_Fclc- SP_Fint4+ SP_Fmph2- SP_Fnum-
CG11419 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11419.
Cell Count:
CG_NumberCategoryR1R2R3
CG11419Primary screen162550143
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11419:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211903.6410056871.7750698420.622336560.272623061-0.917368867-1.013467439-1.035923138-0.441416509-1.5404226812.3638953642.0488048540.979264063-0.3991106040.7844323930.885142687-0.6413411292.050432315-0.2996324891.166622668-1.3882372310.194204035-0.5864052480.360698427
212226-0.7783775261.5219580283.1137072231.9209189041.0660965496.2092278457.1511037467.4190363533.0817451891.6740302151.697078372-0.1298717891.2545473470.9082408061.0335016840.2942239261.4376504750.9154924810.6361921194.1945083481.2950672684.2794729441.889333955
213761.4519642633.8228464022.7654918250.030501891-0.892773232-0.7012282781.767419273-0.609448820.3332448181.1717675761.725258329-0.489344723-0.3335838471.3196651512.409180284-0.2440174571.4740683613.7729100612.9715405562.1433586014.468943846-0.1937600680.380457861
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11419Slide8C0.9861.1580.9190.918
CG11419Slide8O0.0161.4251.4131.627
CG11419Slide8P0.3481.3471.0600.998
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11419 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mitotic anaphaseGO:0000090non-traceable author statement
endomitotic cell cycle
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
anaphase-promoting complexGO:0005680inferred from sequence or structural similarity with EMBL:AF132794; protein_id:AAD30527.1
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
-
Other annotations
DatabaseLink
FlyBaseClick here to see CG11419 in FlyBase
FLIGHTClick here to see CG11419 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11419 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11419
Entrez GeneEntrez Gene page for CG11419
UniprotUniprot page for CG11419

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)