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Gene Page - CG Number : CG11427
Gene Summary - CG11427:

CG11427: The gene ruby is referred to in FlyBase by the symbol Dmel\rb (CG11427, FBgn0003210). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of protein ubiquitination; Notch receptor processing; endocytosis; determination of adult lifespan; negative regulation of gene silencing by RNA; ommochrome biosynthetic process. 19 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; testis pigment cell; secondary pigment cell pigment granule; ocellus pigment granule; tertiary pigment cell pigment granule; photoreceptor cell pigment granule; pigment cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: AP complex subunit beta; AP-3 complex subunit beta; Armadillo-like helical; Armadillo-type fold; Clathrin/coatomer adaptor, adaptin-like, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages.

Gene summary for CG11427 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11427:CG11427 is perturbed in following parameters in primary screen: Fmph1 Fmph2
CG11427 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) NuCellD-(fld)
CG11427 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11427.
Cell Count:
CG_NumberCategoryR1R2R3
CG11427Primary screen400432518
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11427:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211940.8828867311.5366194520.329492807-0.3042331760.1785558183.6677524014.7692227742.6278105391.8160107510.526766698-0.357903385-0.0736608080.5915463590.476968309-0.275941630.5071646871.6828464452.3917770991.7066615331.7086128950.6427436845.2769058225.276408151
212252-0.4454688331.2857028332.151951539-0.832085673-0.0862702883.0303289365.0521855173.1223086632.177576536-0.069702263-0.093869837-0.3481268371.011499334-0.061943244-0.9691132770.6332312070.4240338070.1707065050.2255468652.995313003-0.6106252331.4407176630.351707095
21342-0.0629733430.3004081410.5210836370.5089436671.3438263851.7118267191.0953113212.0446451033.0178877010.3106905060.3226978160.0293021510.2541919870.073737449-0.0942950410.481372355-0.024178746-0.0459354070.1812941653.016402691-0.2467997760.218367792-0.103556185
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11427Slide20C0.8991.0560.9350.966
CG11427Slide20O0.1270.7530.6730.927
CG11427Slide20P0.3301.0061.1151.076
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11427 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
determination of adult lifespanGO:0008340inferred from mutant phenotype
regulation of protein ubiquitination
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
coated vesicleGO:0030135traceable author statement
synaptic vesicle
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein transporter activityGO:0008565inferred from electronic annotation with InterPro:IPR017108
binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11427 in FlyBase
FLIGHTClick here to see CG11427 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11427 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11427
Entrez GeneEntrez Gene page for CG11427
UniprotUniprot page for CG11427

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)