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Gene Page - CG Number : CG11459
Gene Summary - CG11459:

CG11459: This gene is referred to in FlyBase by the symbol Dmel\CG11459 (FBgn0037396). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: cysteine-type peptidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: proteolysis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine peptidase, histidine active site; Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Proteinase inhibitor I29, cathepsin propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed during late larval stages, during early pupal stages, in adult female stages.

Gene summary for CG11459 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11459:CG11459 is perturbed in following parameters in primary screen: Fmph2
CG11459 is perturbed in following parameters in classification assay (fluid): Rto2- Rto3-
CG11459 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11459.
Cell Count:
CG_NumberCategoryR1R2R3
CG11459Primary screen3048621
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11459:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211108-1.1792599030.5558227162.6800225311.631518409-0.0082716851.5111688223.8495488671.5920886470.931088209-0.138805468-0.395295862-0.2277158040.6226940531.77169027-0.255316869-0.6380709330.2619102810.809421027-0.9797561721.4990949221.0324681871.3668355073.015723237
2122683.7714406883.6549177093.5488325781.341589245-1.6908836022.094434033.3922866551.800757527-1.198352680.8377786061.4377184430.1843807660.2211139820.1638356062.596477311-1.8413204380.77837642.186738675-1.29336379-0.659161642-1.5432024410.5626034550.209736705
21358-1.898286611-1.980667246-1.362800599-1.418266873-2.682292318-1.989857188-2.965674551-1.977555163-7.3293713240.677555642-1.7951977961.746543262-2.111891139-1.270533138-0.895669988-2.16648322-0.373509274-1.763534917-2.04506358-5.2229538140.358988469-1.115866963-0.998006458
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11459Slide20C0.1831.0211.2591.463
CG11459Slide20O0.8440.8091.0341.093
CG11459Slide20P0.1671.0151.1971.301
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11459 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508inferred from electronic annotation with InterPro:IPR000169, InterPro:IPR000668
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cysteine-type endopeptidase activityGO:0004197NOT non-traceable author statement
cysteine-type peptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11459 in FlyBase
FLIGHTClick here to see CG11459 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11459 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11459
Entrez GeneEntrez Gene page for CG11459
UniprotUniprot page for CG11459

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)