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Gene Page - CG Number : CG11482
Gene Summary - CG11482:

CG11482: The gene Mlh1 is referred to in FlyBase by the symbol Dmel\Mlh1 (CG11482, FBgn0011659). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: mismatched DNA binding; ATP binding. Based on sequence similarity, it is predicted to be involved in the biological process: mismatch repair. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ATPase-like, ATP-binding domain; DNA mismatch repair protein; DNA mismatch repair protein Mlh1; DNA mismatch repair protein, C-terminal; DNA mismatch repair protein, N-terminal; DNA mismatch repair, conserved site; Ribosomal protein S5 domain 2-type fold; Ribosomal protein S5 domain 2-type fold, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages.

Gene summary for CG11482 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11482:CG11482 is not perturbed in primary screen.
CG11482 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11482.
Cell Count:
CG_NumberCategoryR1R2R3
CG11482Primary screen257414247
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11482:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2111160.3705709010.5128340421.989779850.119814612-0.352032741.9063011174.6134879741.6597623420.539142998-0.281744215-0.043907077-0.331985734-0.1852133850.997081192-0.8108322830.444037913-0.571949857-0.049025705-0.9709363710.5915285633.294838622.5953763771.835823785
212260-0.265429659-0.018988937-0.2455379080.029370242-0.3592582361.3965483332.3363219270.7381036781.1730480431.2935465041.151817046-0.0752938220.1909413130.625655403-0.0331914070.6317237140.4689083570.2846159120.3713028811.535790547-0.7617345593.0340612090.148838403
213500.230059999-0.291011549-0.21029855-0.180538533-0.1176249240.9964286970.1129721651.0467855530.180416478-1.165401463-0.920822257-0.681328937-0.849941432-0.013901168-0.855171714-0.509991026-0.529663331-1.0063618570.524189030.088262123-0.398003222-0.560613009-0.446423826
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11482 is not tested in classification assay
Integrated Annotations for CG11482 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
mismatch repairGO:0006298inferred from sequence or structural similarity
mismatch repair
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from electronic annotation with InterPro:IPR011186
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
mismatched DNA bindingGO:0030983inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11482 in FlyBase
FLIGHTClick here to see CG11482 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11482 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11482
Entrez GeneEntrez Gene page for CG11482
UniprotUniprot page for CG11482

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)