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Gene Page - CG Number : CG11502
Gene Summary - CG11502:

CG11502: The gene seven up is referred to in FlyBase by the symbol Dmel\svp (CG11502, FBgn0003651). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; protein binding; protein heterodimerization activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: phototaxis; neuron-neuron synaptic transmission; photoreceptor cell differentiation; cardioblast cell fate determination; epithelial cell proliferation involved in Malpighian tubule morphogenesis. 67 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; external compound sense organ; organ system subdivision; embryonic/larval neuron; peripheral nervous system; embryonic hindgut; histaminergic neuron; ventral nerve cord primordium; ostium; GW neuron. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Steroid hormone receptor; Transcription factor COUP; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.

Gene summary for CG11502 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11502:CG11502 is not perturbed in primary screen.
CG11502 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11502.
Cell Count:
CG_NumberCategoryR1R2R3
CG11502Primary screen434756207
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11502:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2111220.1405402470.02487901-0.1248982590.3890948150.0438787721.6300411192.4283692791.9800532371.177371581-0.8835325280.0349539240.9396299530.3644740090.7189592880.984450560.412638906-0.573019264-0.159739523-0.4889602131.2156272121.8670414440.1458970220.494563869
212284-0.0572005990.7809129391.3208421630.4890118680.2475412462.9865332024.3540937733.0021497233.189293012-0.4187484860.061083886-0.642101703-0.0414760230.0264131411.4280138870.8689716150.5722225910.3852680081.0820429153.598931278-0.2640319141.6856760930.777372772
21314-0.468758115-0.076601235-0.825336654-1.150785509-1.084956834-0.004054157-0.1094561190.211534975-0.811555623-0.179707613-0.8673295982.049227967-0.725584418-0.9186002382.1229309930.357005-0.699057456-0.063588778-1.463293405-0.1044698290.064743816-0.3354896350.70533552
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11502 is not tested in classification assay
Integrated Annotations for CG11502 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
neuron-neuron synaptic transmissionGO:0007270inferred from mutant phenotype
phototaxis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with HGNC_gene:NR2F2; HGNC:7976; OMIM:107773
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
receptor activityGO:0004872traceable author statement
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11502 in FlyBase
FLIGHTClick here to see CG11502 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11502 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11502
Entrez GeneEntrez Gene page for CG11502
UniprotUniprot page for CG11502

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)