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Gene Page - CG Number : CG11527
Gene Summary - CG11527:

CG11527: The gene Tiggrin is referred to in FlyBase by the symbol Dmel\Tig (CG11527, FBgn0011722). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: axon guidance; cell-substrate adhesion; regulation of cell adhesion mediated by integrin; phagocytosis, engulfment. 10 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; larval abdominal segment; A1-7 ventral longitudinal muscle 3; hypodermal muscle of larval abdominal 2; abdominal 7 longitudinal muscle; abdominal 6 longitudinal muscle; adult segment; adult; abdominal 6 oblique muscle; tracheal system; organ system subdivision. It has one annotated transcript and one annotated polypeptide. Protein features are: Haem oxygenase-like, multi-helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages.

Gene summary for CG11527 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11527:CG11527 is perturbed in following parameters in primary screen: Fclc Tclc
CG11527 is perturbed in following parameters in classification assay (fluid): LP_Fclc+ LP_Fclc- LP_Fint1+ LP_Fint2+ LP_Fint2- LP_Fint3+ LP_Fint3- LP_Fint4- LP_Fmph1+ LP_Fmph1+ LP_Fmph2+ LP_Fmph2+ LP_Fmph3+ LP_Fnum+ LP_Fnum- Okt+(fld) Rto3- SP_Fclc+ SP_Fint1+ SP_Fint2+ SP_Fint2- SP_Fint3+ SP_Fint3- SP_Fmph1+ SP_Fmph1- SP_Fmph2- SP_Fmph3+ SP_Fmph3-
CG11527 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11527.
Cell Count:
CG11527Primary screen611369649
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11527:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11527 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
axon guidanceGO:0007411inferred from mutant phenotype
phagocytosis, engulfment
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
proteinaceous extracellular matrixGO:0005578non-traceable author statement
proteinaceous extracellular matrix
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
bindingGO:0005488traceable author statement
Other annotations
FlyBaseClick here to see CG11527 in FlyBase
FLIGHTClick here to see CG11527 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11527 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11527
Entrez GeneEntrez Gene page for CG11527
UniprotUniprot page for CG11527

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)