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Gene Page - CG Number : CG11551
Gene Summary - CG11551:

CG11551: The gene intermediate neuroblasts defective is referred to in FlyBase by the symbol Dmel\ind (CG11551, FBgn0025776). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; transcription factor binding; sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: central nervous system development; negative regulation of gene expression; regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter. 20 alleles are reported. The phenotypes of these alleles are annotated with: RP2 neuron; neuroblast of ventral nerve cord primordium; intermediate ventral neurectoderm. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11551 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11551:CG11551 is perturbed in following parameters in primary screen: Fmph2 Tint2 Tint4 Tmph1 Tmph2 Tmph3
CG11551 is not perturbed in classification assay (fluid).
CG11551 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint3- Fint4- Fmph1- Fmph2- Fmph3- Fnum- NuCellD+(tfr) NuCirc-(tfr) NuFluct+(tfr) Okt+(tfr) Tclc- Tint4- Tmph1- Tmph2- Tmph3- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11551.
Cell Count:
CG_NumberCategoryR1R2R3
CG11551Primary screen57722219
CG11551Secondary assay92611501030
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11551:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211143-0.4183551140.3909494050.5687141320.5018246410.636191754.661113176.8772372735.2642849253.5699983871.8311880684.127579705-0.2453110221.3300363981.9006154511.506677010.3701415625.5515672683.9114769323.3265619754.793664645-0.477182074.146150142.683233322
212293-0.0807075131.5684688772.0369859670.68610784-0.9205084030.9622658363.0046741780.8874921422.1525983746.0639295844.7336880121.0119206892.3480298112.3477959240.249813881-0.4582275344.0623662715.3323493453.7936720112.5171695441.640876931-0.647132479-0.030455797
21323-1.395444493-1.1856251650.043614703-0.599697365-4.087143824-3.71499082-3.360458658-2.438990285-6.895650618-1.429853321-1.795854446-0.509321126-0.643104698-0.486064849-0.224345272-3.3676102570.927798135-2.17103341-0.507527733-6.732757216-0.5918735070.334826767-1.322701991
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11551Slide20C0.5501.1041.0880.092
CG11551Slide20O0.4601.1050.8950.228
CG11551Slide20P0.4081.0090.9660.074
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11551Slide2F0.3391.0310.9170.765
CG11551Slide2O0.0061.1351.2031.144
CG11551Slide2T0.0660.6010.8340.394
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11551 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of transcription, DNA-dependentGO:0006355inferred from sequence or structural similarity with EMBL:AY436761
ventral cord development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with EMBL:AY436761
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with EMBL:AY436761
transcription factor binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11551 in FlyBase
FLIGHTClick here to see CG11551 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11551 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11551
Entrez GeneEntrez Gene page for CG11551
UniprotUniprot page for CG11551

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)