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Gene Page - CG Number : CG11556
Gene Summary - CG11556:

CG11556: The gene Rabphilin is referred to in FlyBase by the symbol Dmel\Rph (CG11556, FBgn0030230). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process: synaptic vesicle exocytosis; synaptic vesicle endocytosis. 7 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 domain; C2 membrane targeting protein; Rab-binding domain; Rabphilin-3A effector, zinc-binding; Synaptotagmin; Zinc finger, FYVE-related; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11556 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11556:CG11556 is perturbed in following parameters in primary screen: Fmph2
CG11556 is perturbed in following parameters in classification assay (fluid): LP_Fclc- LP_Fint4- Rto2- SP_Fmph1- SP_Fmph2- SP_Fmph3- SP_Fnum-
CG11556 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11556.
Cell Count:
CG11556Primary screen4775544
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11556:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11556 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
neurotransmitter secretionGO:0007269non-traceable author statement
vesicle-mediated transport
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
synaptic vesicleGO:0008021non-traceable author statement
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein transporter activityGO:0008565inferred from sequence or structural similarity with UniProtKB:P47709
zinc ion binding
Other annotations
FlyBaseClick here to see CG11556 in FlyBase
FLIGHTClick here to see CG11556 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11556 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11556
Entrez GeneEntrez Gene page for CG11556
UniprotUniprot page for CG11556

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)