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Gene Page - CG Number : CG11561
Gene Summary - CG11561:

CG11561: The gene smoothened is referred to in FlyBase by the symbol Dmel\smo (CG11561, FBgn0003444). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: blastoderm segmentation; smoothened signaling pathway; eye-antennal disc morphogenesis; ovarian follicle cell development; somatic stem cell maintenance; regulation of mitotic cell cycle; negative regulation of S phase of mitotic cell cycle; eye morphogenesis; Bolwig's organ morphogenesis. 251 alleles are reported. The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: organ system; adult segment; organ system subdivision; larval abdominal segment; thoracic segment; imaginal precursor; portion of tissue; non-connected developing system; tracheal system; abdominal 3 ventral denticle belt; heart primordium; abdominal 5 ventral denticle belt; epithelial furrow; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Frizzled domain; Frizzled protein; Frizzled/secreted frizzled-related protein; GPCR, family 2-like; Smoothened. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11561 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11561:CG11561 is not perturbed in primary screen.
CG11561 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11561.
Cell Count:
CG_NumberCategoryR1R2R3
CG11561Primary screen734856
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11561:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211147-0.868696479-0.93629681-1.2471885990.119118783-1.58698048-1.614977207-1.981956479-2.534956213-3.862917691-1.299539767-0.6433749281.3915861060.6115761150.482610078-0.654108949-1.299972857-1.342970269-2.63064625-3.182904793-3.988447111-0.3271505513.3231120395.580148209
2122890.235417702-0.3038103190.13908097-0.4890413270.4087130150.8530425541.7006683920.6743135891.4264022350.573603910.9396316630.2051989940.2882393350.0737711151.0181288370.1224689580.7782176310.278025250.5950439261.4108217430.0668794871.505212214-0.245604985
213190.8813748710.5983845990.9837929541.387331366-2.862665005-1.310981347-2.213231290.3545673-5.3795238741.7058862231.1825847310.738467472.7986240783.2456969221.618139347-2.3702812861.685889930.4407854553.34253932-5.361037066-1.356287944-1.829195373-1.565317581
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11561 is not tested in classification assay
Integrated Annotations for CG11561 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
Wnt receptor signaling pathwayGO:0016055traceable author statement
blastoderm segmentation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
integral to membraneGO:0016021inferred from sequence or structural similarity
plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
G-protein coupled receptor activityGO:0004930inferred from sequence or structural similarity
G-protein coupled receptor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11561 in FlyBase
FLIGHTClick here to see CG11561 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11561 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11561
Entrez GeneEntrez Gene page for CG11561
UniprotUniprot page for CG11561

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)