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Gene Page - CG Number : CG11579
Gene Summary - CG11579:

CG11579: The gene armadillo is referred to in FlyBase by the symbol Dmel\arm (CG11579, FBgn0000117). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; cadherin binding; RNA polymerase II transcription coactivator activity; kinase binding; transcription coactivator activity. There is experimental evidence for 30 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular component organization or biogenesis; regulation of developmental process; regulation of cellular macromolecule biosynthetic process; sensory organ development; cell adhesion; cell fate commitment; organ morphogenesis; open tracheal system development. 193 alleles are reported. The phenotypes of these alleles are annotated with 107 unique terms, many of which group under: organ system; organ system subdivision; adult segment; abdominal ventral denticle belt; female germline cyst; nervous system; primordium; embryonic/larval neuron; external compound sense organ; embryonic/larval tracheal system. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Armadillo; Armadillo-like helical; Armadillo-type fold; Beta-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.

Gene summary for CG11579 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11579:CG11579 is perturbed in following parameters in primary screen: Fmph2
CG11579 is perturbed in following parameters in classification assay (fluid): NuCellD-(fld) SP_Fint2+ SP_Fint3+
CG11579 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11579.
Cell Count:
CG11579Primary screen291231150
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11579:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11579 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
Wnt receptor signaling pathwayGO:0016055inferred from sequence or structural similarity with MGD:Catnb; MGI:MGI:88276
cytoskeletal anchoring at plasma membrane
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
zonula adherensGO:0005915inferred from direct assay
catenin complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cytoskeletal protein bindingGO:0008092inferred from sequence or structural similarity
alpha-catenin binding
Other annotations
FlyBaseClick here to see CG11579 in FlyBase
FLIGHTClick here to see CG11579 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11579 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11579
Entrez GeneEntrez Gene page for CG11579
UniprotUniprot page for CG11579

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)