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Gene Page - CG Number : CG11607
Gene Summary - CG11607:

CG11607: The gene Homeodomain protein 2.0 is referred to in FlyBase by the symbol Dmel\H2.0 (CG11607, FBgn0001170). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of transcription, DNA-dependent. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages.

Gene summary for CG11607 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11607:CG11607 is perturbed in following parameters in primary screen: Fmph2 Tclc
CG11607 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fint4+ NuCellD-(fld) NuCirc+(fld) NuFluct-(fld) NuSize-(fld) Okt+(fld) SP_Fint3+ SP_Fmph2- SP_Fmph3-
CG11607 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11607.
Cell Count:
CG_NumberCategoryR1R2R3
CG11607Primary screen646214133
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11607:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211172-0.2781268970.9204577531.220839265-0.1633037641.0493481934.5332308446.6735808964.3372043692.6880197450.7202022190.515675357-0.4690492390.9650034180.7570679040.1098877470.5413991941.882829371.1666474340.962356523.3367425060.9991856121.3339093861.644874464
212144-0.3033378540.7739627962.932772474-0.11919297-0.5710306252.4278652094.1868045212.3867530311.9776193942.0520500553.647825628-0.2649106662.1438723811.241406389-0.174154916-0.6727127481.8500105535.1052606761.9917892363.455081040.6961000750.710038447-0.371826041
213294-0.591099863-0.082948029-0.992371146-0.627634396-0.450793203-2.651133401-2.448534186-2.772078919-2.779564841-0.88098861-1.131098584-0.8136301460.5495186090.0322626040.325754773-0.6280845340.8015316191.2585850570.696941037-2.8618650732.79682329-0.253079322-0.684706397
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11607Slide8C0.5681.0590.9301.135
CG11607Slide8O0.0151.2121.3911.271
CG11607Slide8P0.0441.1231.0401.097
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11607 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of transcription, DNA-dependentGO:0006355inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR012287, InterPro:IPR017970
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from sequence or structural similarity with UniProtKB:Q14774
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
sequence-specific DNA binding transcription factor activityGO:0003700inferred from sequence or structural similarity with UniProtKB:Q14774
sequence-specific DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11607 in FlyBase
FLIGHTClick here to see CG11607 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11607 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11607
Entrez GeneEntrez Gene page for CG11607
UniprotUniprot page for CG11607

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)