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Gene Page - CG Number : CG11621
Gene Summary - CG11621:

CG11621: The gene Phosphotidylinositol 3 kinase 68D is referred to in FlyBase by the symbol Dmel\Pi3K68D (CG11621, FBgn0015278). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phospholipid binding; 1-phosphatidylinositol-4-phosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity. There is experimental evidence that it is involved in the biological process: phosphatidylinositol phosphorylation; response to DNA damage stimulus; phagocytosis, engulfment. 13 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval hemocyte; macrophage. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Armadillo-type fold; C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Phosphatidylinositol 3-/4-kinase, catalytic domain; Phosphatidylinositol 3-kinase C2 (PI3K C2) domain; Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain; Phosphatidylinositol 3/4-kinase, conserved site; Phosphatidylinositol Kinase; Phosphoinositide 3-kinase, accessory (PIK) domain; Phox homologous domain; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.

Gene summary for CG11621 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11621:CG11621 is perturbed in following parameters in primary screen: Fint1 Fint2 Fint3 Fmph1 Fmph2 Fmph3 Tclc
CG11621 is perturbed in following parameters in classification assay (fluid): LP_Fint2- LP_Fint3- NuCellD-(fld) SP_Fclc- SP_Fint2- SP_Fint3-
CG11621 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11621.
Cell Count:
CG11621Primary screen567567185
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11621:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11621 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
phosphatidylinositol phosphorylationGO:0046854inferred from direct assay
phosphatidylinositol phosphorylation
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:0046934NOT inferred from direct assay
1-phosphatidylinositol-3-kinase activity
Other annotations
FlyBaseClick here to see CG11621 in FlyBase
FLIGHTClick here to see CG11621 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11621 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11621
Entrez GeneEntrez Gene page for CG11621
UniprotUniprot page for CG11621

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)