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Gene Page - CG Number : CG11680
Gene Summary - CG11680:

CG11680: The gene maleless is referred to in FlyBase by the symbol Dmel\mle (CG11680, FBgn0002774). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: male courtship behavior, veined wing generated song production; positive regulation of transcription from RNA polymerase II promoter; determination of adult lifespan; dosage compensation; axon extension. 58 alleles are reported. The phenotypes of these alleles are annotated with: giant fiber neuron; NMJ bouton; polytene chromosome; embryonic/larval neuromuscular junction; wing; adult brain; spermatozoon. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Domain of unknown function DUF1605; Double-stranded RNA-binding; Double-stranded RNA-binding-like; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; Helicase-associated domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period.

Gene summary for CG11680 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11680:CG11680 is perturbed in following parameters in primary screen: Fmph2
CG11680 is not perturbed in classification assay (fluid).
CG11680 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11680.
Cell Count:
CG_NumberCategoryR1R2R3
CG11680Primary screen47719686
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11680:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2112011.207017406-0.2021981351.2062167641.6415211930.045652992.0339228564.2708768531.6838605621.5043206471.3544380280.216871598-0.7160215251.4968344621.5231208580.8119163670.031683567-0.194442055-0.052430053-0.9014318011.964103501-0.61310075-0.723963696-0.186565868
2121156.2121100332.3805028391.825373398-0.917392708-0.8855535731.4839146914.0361778651.0127995522.139997995.6617344475.7088297311.9481549592.8157511872.4093188221.1401821140.2958855146.4276368565.127445038.6103035182.294170887-0.509672452-0.2394502341.110073752
213265-1.362201769-1.051924289-1.053159103-0.539853189-1.660533202-1.354040698-1.612629298-1.630635884-2.8406126080.7798736980.354122617-0.537232777-1.4044812910.044689036-1.707154692-1.9452168572.795143425-0.7205461051.972321634-2.1752718990.214676436-1.04611735-1.523993006
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11680Slide20C0.6201.4950.8421.015
CG11680Slide20O0.8370.8931.0731.145
CG11680Slide20P0.2271.0030.8930.890
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11680 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dosage compensationGO:0007549inferred from mutant phenotype
dosage compensation by hyperactivation of X chromosome
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
chromatinGO:0000785inferred from direct assay
X chromosome located dosage compensation complex, transcription activating
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
ATP-dependent helicase activityGO:0008026traceable author statement
chromatin binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11680 in FlyBase
FLIGHTClick here to see CG11680 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11680 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11680
Entrez GeneEntrez Gene page for CG11680
UniprotUniprot page for CG11680

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)