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Gene Page - CG Number : CG11734
Gene Summary - CG11734:

CG11734: The gene HERC2 is referred to in FlyBase by the symbol Dmel\HERC2 (CG11734, FBgn0031107). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquitin-protein ligase activity; guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: protein ubiquitination. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Anaphase-promoting complex, subunit 10/DOC domain; CPH domain; CUB; Cytochrome b5; Galactose-binding domain-like; HECT; Mib-herc2; Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Translation protein SH3-like, subgroup; UBA-like; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG11734 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11734:CG11734 is not perturbed in primary screen.
CG11734 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11734.
Cell Count:
CG_NumberCategoryR1R2R3
CG11734Primary screen34611771
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11734:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2112140.6863670071.6745894042.5448147420.5670187590.3934189073.5536615937.2488493473.5679577151.411247304-0.348096413-0.3591294040.275630905-0.2256766340.3994420451.494348424-0.1311471130.270041991-0.274554523-0.7001289042.249883505-0.4228752251.7062657452.392334728
212722.1593868962.0609613291.554431680.913076987-1.8569103941.3531891472.0643175141.488874177-1.7573861130.1455156530.8715204080.350412081-0.9960658010.884381812-1.039474478-1.78138423-0.170635088-0.226121645-1.256888244-1.0644000640.1173005320.2759315091.313945175
2132220.944554088-0.932134143-0.645708469-0.58343187-1.675910457-1.6470619430.07022897-1.667226188-2.3122369680.880142887-1.0749064141.068890179-0.829425853-0.3921289381.153565572-1.8133815030.1155652690.5572222980.13048880.143629158-0.591421614-0.726618247-0.180149684
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11734 is not tested in classification assay
Integrated Annotations for CG11734 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein ubiquitinationGO:0016567inferred from electronic annotation with InterPro:IPR010606
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
intracellularGO:0005622inferred from electronic annotation with InterPro:IPR000569
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
guanyl-nucleotide exchange factor activityGO:0005085non-traceable author statement
ubiquitin-protein ligase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11734 in FlyBase
FLIGHTClick here to see CG11734 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11734 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11734
Entrez GeneEntrez Gene page for CG11734
UniprotUniprot page for CG11734

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)