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Gene Page - CG Number : CG1179
Gene Summary - CG1179:

CG1179: The gene Lysozyme B is referred to in FlyBase by the symbol Dmel\LysB (CG1179, FBgn0004425). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: lysozyme activity. It is reported to be involved in the biological process: antimicrobial humoral response. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Glycoside hydrolase, family 22; Glycoside hydrolase, family 22, conserved site; Glycoside hydrolase, family 22, lysozyme; Lysozyme-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed at stages throughout the larval period.

Gene summary for CG1179 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG1179:CG1179 is perturbed in following parameters in primary screen: NuCellD Tclc Tmph2
CG1179 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- NuCirc+(fld) NuSize-(fld) SP_Fint4- SP_Fmph2+
CG1179 is perturbed in following parameters in classification assay (transferrin): Fint4- Tint4-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG1179.
Cell Count:
CG_NumberCategoryR1R2R3
CG1179Primary screen607342588
CG1179Secondary assay9891100689
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG1179:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1179Slide11C0.0361.2181.4831.614
CG1179Slide11O0.1081.1181.3581.550
CG1179Slide11P0.2880.9771.2941.946
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG1179Slide10F0.1861.3110.9941.345
CG1179Slide10O0.4880.8071.1420.726
CG1179Slide10T0.9951.3080.7630.926
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG1179 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
antimicrobial humoral responseGO:0019730non-traceable author statement
cell wall macromolecule catabolic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
lysozyme activityGO:0003796inferred from sequence or structural similarity
lysozyme activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG1179 in FlyBase
FLIGHTClick here to see CG1179 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG1179 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG1179
Entrez GeneEntrez Gene page for CG1179
UniprotUniprot page for CG1179

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)