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Gene Page - CG Number : CG11840
Gene Summary - CG11840:

CG11840: The gene Signal peptide protease is referred to in FlyBase by the symbol Dmel\Spp (CG11840, FBgn0031260). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: aspartic endopeptidase activity, intramembrane cleaving. There is experimental evidence that it is involved in the biological process: cellular response to unfolded protein; signal peptide processing; open tracheal system development. 16 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; embryonic/larval tracheal system. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase A22, presenilin signal peptide; Peptidase A22B, signal peptide peptidase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages.

Gene summary for CG11840 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11840:CG11840 is not perturbed in primary screen.
CG11840 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11840.
Cell Count:
CG_NumberCategoryR1R2R3
CG11840Primary screen133340196
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11840:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211260-1.3351920940.5760481011.624535896-0.320683406-1.190978374-0.9969796950.7817632730.463704879-2.2276894780.8892994-0.6453521240.903901878-0.76769527-0.346443267-0.1950772-1.43360037-1.775483372-2.001003479-2.385714917-1.930197235-1.6874002770.045397021.839042242
21256-0.350792784-0.289688994-0.4825789980.069588702-0.3029908380.2763337850.5577289740.5164972160.3184794390.628685049-0.1487040953.1601379582.9421971582.374336885-0.612468367-0.6947330870.005343922-0.764615879-0.1823479880.480205586-0.184456074-0.580408354-0.730026022
2132062.775032379-0.539646314-0.39584019-0.513660928-0.3123203790.306870330.0481272620.083927541-0.543922860.260004366-0.335048104-0.126145142-0.235992148-0.6148664740.902041527-0.357983184-0.913379381-0.572512835-0.350751543-0.5162916212.030134476-0.8662102040.274588891
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11840 is not tested in classification assay
Integrated Annotations for CG11840 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
open tracheal system developmentGO:0007424inferred from mutant phenotype
membrane protein proteolysis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
endoplasmic reticulumGO:0005783inferred from direct assay
integral to membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
aspartic endopeptidase activity, intramembrane cleavingGO:0042500inferred from direct assay
aspartic endopeptidase activity, intramembrane cleaving
Other annotations
DatabaseLink
FlyBaseClick here to see CG11840 in FlyBase
FLIGHTClick here to see CG11840 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11840 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11840
Entrez GeneEntrez Gene page for CG11840
UniprotUniprot page for CG11840

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)