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Gene Page - CG Number : CG11856
Gene Summary - CG11856:

CG11856: The gene Nucleoporin 358 is referred to in FlyBase by the symbol Dmel\Nup358 (CG11856, FBgn0039302). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Ran GTPase binding. There is experimental evidence that it is involved in the biological process: NLS-bearing substrate import into nucleus; SMAD protein import into nucleus; protein import into nucleus. 4 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; tormogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Pleckstrin homology-like domain; Ran binding domain; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical; Zinc finger, RanBP2-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11856 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11856:CG11856 is not perturbed in primary screen.
CG11856 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11856.
Cell Count:
CG_NumberCategoryR1R2R3
CG11856Primary screen11390492
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11856:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2112710.048721785-0.6166877190.267493866-0.726414952-2.259094298-3.277353374-4.326753449-3.403782349-6.021767785-1.958877847-1.033831498-1.1803786980.5589738471.958329708-1.965388556-3.224747937-1.808135834-3.275772252-0.987381912-6.232084527-0.800135028-0.724180114-1.164292449
212150.823654914-0.4972405410.52007733-1.227639447-0.3269797022.1642385144.2447780512.0202044531.7975393660.3662866581.3635402610.399439481.3153067130.1090093850.1657613130.1188013560.5309880721.575426410.6845382922.607249418-0.603082178-0.794864707-0.564176208
213165-0.484995807-0.281800681-0.103342278-0.6674425551.712383271.156649064-0.0650846711.0061265371.221968961-0.422717492-0.1773581930.100441653-0.400657703-0.581298608-0.1449265730.9293139781.078232415-0.2936337251.3573303460.6324092480.1002779411.4260236880.371050247
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11856 is not tested in classification assay
Integrated Annotations for CG11856 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
NLS-bearing substrate import into nucleusGO:0006607inferred from mutant phenotype
SMAD protein import into nucleus
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nuclear poreGO:0005643inferred from sequence or structural similarity with UniProtKB:P48820
lipid particle
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
Ran GTPase bindingGO:0008536inferred from sequence or structural similarity with UniProtKB:P48820
zinc ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11856 in FlyBase
FLIGHTClick here to see CG11856 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11856 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11856
Entrez GeneEntrez Gene page for CG11856
UniprotUniprot page for CG11856

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)