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Gene Page - CG Number : CG11859
Gene Summary - CG11859:

CG11859: This gene is referred to in FlyBase by the symbol Dmel\CG11859 (FBgn0039306). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase-like domain; RIO kinase, conserved site; RIO-like kinase; RIO2 kinase, winged helix, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages.

Gene summary for CG11859 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11859:CG11859 is perturbed in following parameters in primary screen: Fmph1 Fmph2 Tclc
CG11859 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) LP_Fint2+ LP_Fint3+ NuCellD-(fld) NuFluct-(fld) Okt+(fld) SP_Fint2+ SP_Fint3+
CG11859 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11859.
Cell Count:
CG_NumberCategoryR1R2R3
CG11859Primary screen537510159
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11859:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211274-0.2527594850.5144858092.305981879-0.0541476240.8720835134.4645654996.1752090412.6333274942.12502046-0.0980948840.4750353010.1818503410.5550344040.5447650191.1788176020.7452948551.1603302160.838548910.3829522513.1672626290.4786779790.903040473-0.516105879
21212-0.3677676490.5090151711.2711192280.662529611.6346915884.8298164925.2078221565.3987966624.1345956961.717481254.0889097-0.6000586732.5869893731.905224993-0.1258066050.5404276883.1784115044.5749462573.1673242185.2575753620.5405029441.2923731750.598062722
2131621.1916272960.6953694951.0731818961.533736124-0.967078859-0.4053908620.909505462-0.156488159-1.3152513810.1611688241.141915825-0.199343895-0.0094418830.236023370.236570975-0.8846680580.057600265-1.370282139-0.233554330.3389088831.918593963.366038485-0.232118343
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11859Slide8C0.0851.1181.1001.291
CG11859Slide8O0.0551.1861.4791.500
CG11859Slide8P0.0181.1351.2861.279
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11859 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
protein phosphorylationGO:0006468non-traceable author statement
neurogenesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein kinase activityGO:0004672non-traceable author statement
ATP binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11859 in FlyBase
FLIGHTClick here to see CG11859 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11859 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11859
Entrez GeneEntrez Gene page for CG11859
UniprotUniprot page for CG11859

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)