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Gene Page - CG Number : CG11864
Gene Summary - CG11864:

CG11864: This gene is referred to in FlyBase by the symbol Dmel\CG11864 (FBgn0028944). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction; proteolysis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Metallopeptidase, catalytic domain; Peptidase M12A, astacin; Peptidase, metallopeptidase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed in adult male stages.

Gene summary for CG11864 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11864:CG11864 is perturbed in following parameters in primary screen: Fmph1 Fmph2 Tclc
CG11864 is perturbed in following parameters in classification assay (fluid): NuCellD-(fld) NuCirc-(fld) NuSize+(fld) Okt-(fld) Rto1+ SP_Fint1+
CG11864 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11864.
Cell Count:
CG_NumberCategoryR1R2R3
CG11864Primary screen459552149
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11864:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211277-0.310797212-0.2488911350.713945848-0.7885159440.4288110594.3437136596.546936375.6503346442.590832110.3171662560.567866006-0.1493241331.1356218692.117399719-0.0472294340.0895705661.4180824431.0439555930.5890567623.292411328-0.642711429-0.538259643-0.500713163
21291.644561619-0.1552589381.3371866591.8354123790.0270979943.1884860354.844691952.9411195213.065366545-0.0555858841.561380661-0.7757653990.8446422210.2712646860.5786001310.3135963970.5441524131.8016995150.5518692583.608940430.7621634094.0282640871.102177025
2131591.316964470.5405500171.5571097430.528451148-1.31952951-0.6336374490.673001815-0.662706165-1.441614177-0.461202355-0.613551173-1.269673786-0.905390233-1.259476307-0.03169067-1.010446834-0.9915521120.269284648-0.831798799-0.2189805910.1314783110.3341947370.584249431
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11864Slide20C0.3460.5810.7581.071
CG11864Slide20O0.0250.2230.3540.585
CG11864Slide20P0.7750.6650.9961.612
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11864 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508inferred from sequence or structural similarity
proteolysis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
extracellular spaceGO:0005615inferred from direct assay
extracellular space
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
metalloendopeptidase activityGO:0004222inferred from sequence or structural similarity
metalloendopeptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11864 in FlyBase
FLIGHTClick here to see CG11864 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11864 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11864
Entrez GeneEntrez Gene page for CG11864
UniprotUniprot page for CG11864

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)