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Gene Page - CG Number : CG11874
Gene Summary - CG11874:

CG11874: The gene α Mannosidase Ib is referred to in FlyBase by the symbol Dmel\α-Man-Ib (CG11874, FBgn0039634). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. There is experimental evidence that it is involved in the biological process: encapsulation of foreign target. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Glycoside hydrolase, family 47. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in adult female stages.

Gene summary for CG11874 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11874:CG11874 is perturbed in following parameters in primary screen: Fclc Fmph1 Fmph2 NuSize Tclc
CG11874 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- LP_Fnum- NuCellD-(fld) NuCirc+(fld) NuSize-(fld) Okt+(fld) Rto1- SP_Fint4- SP_Fnum-
CG11874 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1+ Fmph3+ Rto1+(tfr) Rto2+(tfr) Tint1+ Tint2+
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11874.
Cell Count:
CG_NumberCategoryR1R2R3
CG11874Primary screen474528408
CG11874Secondary assay681845861
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11874:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
211282-0.206270163-0.418007867-0.28830496-0.5836978270.3474287823.0930622545.6040768812.8711007342.5021955071.60216860.4117154980.1105402610.2588441261.7887557561.4532835030.5349812670.661676750.6116550820.0748469063.2770123110.1093983263.8223296912.600041149
2124-0.547613592.3122310684.0505672640.5075050671.6410520416.6095643837.9231424447.3867960524.7614740543.1492668394.3621488390.1516815142.0731992121.911947398-0.2488066350.2291102743.0190408096.54035133.84783895.845051454-0.311421484.3441154462.295814518
2131540.422324543-0.488915045-0.5156273880.9172256471.425303521.4693251221.3882090761.7079740293.504112369-0.324562207-0.6141500320.392920116-0.412541641.041590079-0.5121871060.964233385-0.2916315741.300071939-0.1403485292.6870269090.6974235190.229413918-0.542406985
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11874Slide11C0.0011.3701.5461.515
CG11874Slide11O0.0481.0721.1961.142
CG11874Slide11P0.4780.8221.5091.198
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11874Slide10F0.0021.4181.3181.276
CG11874Slide10O0.5070.9970.9730.973
CG11874Slide10T0.7941.1100.9721.002
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11874 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
-
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
membraneGO:0016020inferred from electronic annotation with InterPro:IPR001382
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
mannosyl-oligosaccharide 1,2-alpha-mannosidase activityGO:0004571inferred from sequence or structural similarity with UniProtKB:Q9UKM7
calcium ion binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11874 in FlyBase
FLIGHTClick here to see CG11874 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11874 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11874
Entrez GeneEntrez Gene page for CG11874
UniprotUniprot page for CG11874

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)