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Gene Page - CG Number : CG11876
Gene Summary - CG11876:

CG11876: This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.

Gene summary for CG11876 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11876:CG11876 is not perturbed in primary screen.
CG11876 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11876.
Cell Count:
CG_NumberCategoryR1R2R3
CG11876Primary screen417377234
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11876:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
2112830.721233504-0.3373957150.5963999471.813567651-0.0567829411.8583957842.8548880331.7579109061.4437282950.3895902841.713553514-0.6710864430.1264607860.130378794-0.0970330570.1646913480.372581862-0.043000589-1.0206231591.3616524570.1993187830.219089991-0.201142496
21233.832544072.105206173.9283087062.3445205040.8698027774.2233583576.9177686094.649760764.400132183.5294325025.5988845920.595328411.9566398141.277920018-0.2779819530.2786377625.9578621427.6734618617.6533667795.086918724-0.787433835-0.5506084590.042502231
213153-0.8336653040.058162886-0.0694410530.096656713-0.0168909831.6800471651.7964159921.763943662.080726047-0.4668499980.0459295421.040080506-0.6106174270.167970439-0.771030545-0.586992381-0.1046226162.7396612140.3749753572.162092744-0.3540227493.4412340960.163788293
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11876 is not tested in classification assay
Integrated Annotations for CG11876 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
pyruvate metabolic processGO:0006090inferred from sequence or structural similarity with UniProtKB:P29803
cytoplasmic microtubule organization
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
pyruvate dehydrogenase complexGO:0045254inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425
pyruvate dehydrogenase complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
pyruvate dehydrogenase (acetyl-transferring) activityGO:0004739inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425
pyruvate dehydrogenase (acetyl-transferring) activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11876 in FlyBase
FLIGHTClick here to see CG11876 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11876 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11876
Entrez GeneEntrez Gene page for CG11876
UniprotUniprot page for CG11876

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)