.:: RNAiDB - Gene Page ::. Gene Page - CG Number : CG11876Gene Summary - CG11876:CG11876: This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Gene summary for CG11876 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)Experimental Summary - CG11876:CG11876 is not perturbed in primary screen. CG11876 is not tested in classification assay. Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11876.Cell Count:CG_NumberCategoryR1R2R3CG11876Primary screen417377234R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3Primary screen data - CG11876: SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize2112830.721233504-0.3373957150.5963999471.813567651-0.0567829411.8583957842.8548880331.7579109061.4437282950.3895902841.713553514-0.6710864430.1264607860.130378794-0.0970330570.1646913480.372581862-0.043000589-1.0206231591.3616524570.1993187830.219089991-0.20114249621233.832544072.105206173.9283087062.3445205040.8698027774.2233583576.9177686094.649760764.400132183.5294325025.5988845920.595328411.9566398141.277920018-0.2779819530.2786377625.9578621427.6734618617.6533667795.086918724-0.787433835-0.5506084590.042502231213153-0.8336653040.058162886-0.0694410530.096656713-0.0168909831.6800471651.7964159921.763943662.080726047-0.4668499980.0459295421.040080506-0.6106174270.167970439-0.771030545-0.586992381-0.1046226162.7396612140.3749753572.162092744-0.3540227493.4412340960.163788293 SN: Slide Number; RN: Replicate Number; WN: Well NumberExperimental Data (Classification Assay):CG11876 is not tested in classification assayIntegrated Annotations for CG11876 :Gene Ontology Annoations: Biological ProcessBiological Process - TermGO IDEvidencepyruvate metabolic processGO:0006090inferred from sequence or structural similarity with UniProtKB:P29803 cytoplasmic microtubule organizationGene Ontology Annoations: Cellular ComponentCellular Component - TermGO IDEvidencepyruvate dehydrogenase complexGO:0045254inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase complexGene Ontology Annoations: Molecular FunctionMolecular Function - TermGO IDEvidencepyruvate dehydrogenase (acetyl-transferring) activityGO:0004739inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase (acetyl-transferring) activity Other annotations DatabaseLinkFlyBaseClick here to see CG11876 in FlyBaseFLIGHTClick here to see CG11876 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)BioGRIDClick here to see CG11876 in BioGRID (Interaction Summary)Off-targetClick here for Off-target data for CG11876Entrez GeneEntrez Gene page for CG11876UniprotUniprot page for CG11876 Endosite Team : Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in) Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)
.:: RNAiDB - Gene Page ::. Gene Page - CG Number : CG11876Gene Summary - CG11876:CG11876: This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Gene summary for CG11876 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)Experimental Summary - CG11876:CG11876 is not perturbed in primary screen. CG11876 is not tested in classification assay. Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11876.Cell Count:CG_NumberCategoryR1R2R3CG11876Primary screen417377234R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3Primary screen data - CG11876: SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize2112830.721233504-0.3373957150.5963999471.813567651-0.0567829411.8583957842.8548880331.7579109061.4437282950.3895902841.713553514-0.6710864430.1264607860.130378794-0.0970330570.1646913480.372581862-0.043000589-1.0206231591.3616524570.1993187830.219089991-0.20114249621233.832544072.105206173.9283087062.3445205040.8698027774.2233583576.9177686094.649760764.400132183.5294325025.5988845920.595328411.9566398141.277920018-0.2779819530.2786377625.9578621427.6734618617.6533667795.086918724-0.787433835-0.5506084590.042502231213153-0.8336653040.058162886-0.0694410530.096656713-0.0168909831.6800471651.7964159921.763943662.080726047-0.4668499980.0459295421.040080506-0.6106174270.167970439-0.771030545-0.586992381-0.1046226162.7396612140.3749753572.162092744-0.3540227493.4412340960.163788293 SN: Slide Number; RN: Replicate Number; WN: Well NumberExperimental Data (Classification Assay):CG11876 is not tested in classification assayIntegrated Annotations for CG11876 :Gene Ontology Annoations: Biological ProcessBiological Process - TermGO IDEvidencepyruvate metabolic processGO:0006090inferred from sequence or structural similarity with UniProtKB:P29803 cytoplasmic microtubule organizationGene Ontology Annoations: Cellular ComponentCellular Component - TermGO IDEvidencepyruvate dehydrogenase complexGO:0045254inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase complexGene Ontology Annoations: Molecular FunctionMolecular Function - TermGO IDEvidencepyruvate dehydrogenase (acetyl-transferring) activityGO:0004739inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase (acetyl-transferring) activity Other annotations DatabaseLinkFlyBaseClick here to see CG11876 in FlyBaseFLIGHTClick here to see CG11876 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)BioGRIDClick here to see CG11876 in BioGRID (Interaction Summary)Off-targetClick here for Off-target data for CG11876Entrez GeneEntrez Gene page for CG11876UniprotUniprot page for CG11876
CG11876: This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.
Endosite Team : Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in) Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)