Gene Page - CG Number : CG11876

Gene Summary - CG11876:

CG11876: This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.

Gene summary for CG11876 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG11876:

CG11876 is not perturbed in primary screen.
CG11876 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG11876.

Cell Count:

CG_Number	Category	R1	R2	R3
CG11876	Primary screen	417	377	234

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG11876:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize
21	1	283	0.721233504	-0.337395715	0.596399947	1.813567651	-0.056782941	1.858395784	2.854888033	1.757910906	1.443728295	0.389590284	1.713553514	-0.671086443	0.126460786	0.130378794	-0.097033057	0.164691348	0.372581862	-0.043000589	-1.020623159	1.361652457	0.199318783	0.219089991	-0.201142496
21	2	3	3.83254407	2.10520617	3.928308706	2.344520504	0.869802777	4.223358357	6.917768609	4.64976076	4.40013218	3.529432502	5.598884592	0.59532841	1.956639814	1.277920018	-0.277981953	0.278637762	5.957862142	7.673461861	7.653366779	5.086918724	-0.787433835	-0.550608459	0.042502231
21	3	153	-0.833665304	0.058162886	-0.069441053	0.096656713	-0.016890983	1.680047165	1.796415992	1.76394366	2.080726047	-0.466849998	0.045929542	1.040080506	-0.610617427	0.167970439	-0.771030545	-0.586992381	-0.104622616	2.739661214	0.374975357	2.162092744	-0.354022749	3.441234096	0.163788293

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG11876 is not tested in classification assay

Integrated Annotations for CG11876 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
pyruvate metabolic process	GO:0006090	inferred from sequence or structural similarity with UniProtKB:P29803 cytoplasmic microtubule organization

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
pyruvate dehydrogenase complex	GO:0045254	inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase complex

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
pyruvate dehydrogenase (acetyl-transferring) activity	GO:0004739	inferred from sequence or structural similarity with SGD_LOCUS:PDB1; SGD:S0000425 pyruvate dehydrogenase (acetyl-transferring) activity

Other annotations

Database	Link
FlyBase	Click here to see CG11876 in FlyBase
FLIGHT	Click here to see CG11876 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG11876 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG11876
Entrez Gene	Entrez Gene page for CG11876
Uniprot	Uniprot page for CG11876

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)