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Gene Page - CG Number : CG11924
Gene Summary - CG11924:

CG11924: The gene Chorion factor 2 is referred to in FlyBase by the symbol Dmel\Cf2 (CG11924, FBgn0000286). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence that it is involved in the biological process: adult somatic muscle development; positive regulation of transcription elongation from RNA polymerase II promoter. 21 alleles are reported. The phenotypes of these alleles are annotated with: myosin filament; mesothoracic extracoxal depressor muscle 66; Z disc; follicle cell; mesothoracic tergum; trichogen cell; egg chamber; dorsal appendage; M band; indirect flight muscle. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in stages of adults of both sexes.

Gene summary for CG11924 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11924:CG11924 is perturbed in following parameters in primary screen: Fmph2
CG11924 is perturbed in following parameters in classification assay (fluid): LP_Fnum+
CG11924 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11924.
Cell Count:
CG_NumberCategoryR1R2R3
CG11924Primary screen459546220
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11924:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22113-0.208560445-0.434264284-0.1971833581.2527193480.2206211941.3431976333.0919928781.2898518481.1952815121.0027918680.1550348250.097475091-0.046148667-0.450850468-0.2735665980.096686475-1.204238773-0.415412208-1.112396361.056654002-0.3164254560.0762096761.089691237
2221530.1194185243.0311131514.8198317552.8680641660.7621483586.1892883275.3988255786.9642012594.9280784140.0745574541.0647120060.6587907170.9749023151.3467695790.3855809940.2763437741.2254908132.8065910151.3666691642.738217809-0.0986985165.7398318334.278103248
223123-0.777249594-0.175429656-0.766218206-0.654634955-0.814525088-0.659011428-0.747321018-0.616422154-3.725740438-0.332298953-1.276438348-0.247211584-0.8355605180.4045165461.4161239341.383764866-0.742471809-1.297840360.938898774-1.9144856232.1135460381.6319456361.232863533
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11924Slide21C0.4281.0200.9870.155
CG11924Slide21O0.5331.0871.0560.221
CG11924Slide21P0.3570.9620.9400.157
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11924 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
regulation of transcription, DNA-dependentGO:0006355non-traceable author statement
adult somatic muscle development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
nucleusGO:0005634inferred from direct assay
nucleus
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677non-traceable author statement
sequence-specific DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11924 in FlyBase
FLIGHTClick here to see CG11924 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11924 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11924
Entrez GeneEntrez Gene page for CG11924
UniprotUniprot page for CG11924

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)