Gene Page - CG Number : CG1193

Gene Summary - CG1193:

CG1193: The gene katanin p60-like 1 is referred to in FlyBase by the symbol Dmel\kat-60L1 (CG1193, FBgn0037375). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity; microtubule binding. There is experimental evidence that it is involved in the biological process: positive regulation of dendrite morphogenesis; neuron remodeling. 9 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; dendrite; class IV dendritic arborizing neuron; dorsal multidendritic neuron ddaC; dorsal cluster neuron. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Vps4 oligomerisation, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed in adult male stages.

Gene summary for CG1193 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)

Experimental Summary - CG1193:

CG1193 is perturbed in following parameters in primary screen: Rto1
CG1193 is not tested in classification assay.

Cellular phenotyping(Images):

Click here to access phenotyping images of gene CG1193.

Cell Count:

CG_Number	Category	R1	R2	R3
CG1193	Primary screen	289	510	606

R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3

Primary screen data - CG1193:

SN	RN	WN	Fint1	Fint2	Fint3	Fint4	Fnum	Fmph1	Fmph2	Fmph3	Fclc	Tint1	Tint2	Tint3	Tint4	Rto1	Rto2	Rto3	Okt	Tnum	Tmph1	Tmph2	Tmph3	Tclc	CellSize

SN: Slide Number; RN: Replicate Number; WN: Well Number

Experimental Data (Classification Assay):

CG1193 is not tested in classification assay

Integrated Annotations for CG1193 :

Gene Ontology Annoations: Biological Process

Biological Process - Term	GO ID	Evidence
microtubule severing	GO:0051013	inferred from sequence or structural similarity with NCBI_gi:3283072 microtubule-based process

Gene Ontology Annoations: Cellular Component

Cellular Component - Term	GO ID	Evidence
endoplasmic reticulum	GO:0005783	inferred from sequence or structural similarity with EMBL:AF052191 katanin complex

Gene Ontology Annoations: Molecular Function

Molecular Function - Term	GO ID	Evidence
ATPase activity	GO:0016887	inferred from sequence or structural similarity with EMBL:AF052191 microtubule binding

Other annotations

Database	Link
FlyBase	Click here to see CG1193 in FlyBase
FLIGHT	Click here to see CG1193 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRID	Click here to see CG1193 in BioGRID (Interaction Summary)
Off-target	Click here for Off-target data for CG1193
Entrez Gene	Entrez Gene page for CG1193
Uniprot	Uniprot page for CG1193

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Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)