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Gene Page - CG Number : CG11963
Gene Summary - CG11963:

CG11963: The gene skpA associated protein is referred to in FlyBase by the symbol Dmel\skap (CG11963, FBgn0037643). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: succinate-CoA ligase (ADP-forming) activity. There is experimental evidence that it is involved in the biological process: regulation of centrosome duplication; mitotic spindle organization. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp fold; ATP-grasp fold, subdomain 1; ATP-grasp fold, subdomain 2; ATP-grasp fold, succinyl-CoA synthetase-type; Succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase, beta subunit, conserved site; Succinyl-CoA synthetase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG11963 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11963:CG11963 is not perturbed in primary screen.
CG11963 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11963.
Cell Count:
CG_NumberCategoryR1R2R3
CG11963Primary screen266100315
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11963:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
221300.3599976531.6578176161.995313019-0.7725616180.1806279873.0103764346.0948968021.8702089520.653430563-0.769111487-0.747661936-0.3606460520.0410414630.0482034470.997566512-0.429324435-0.1205826540.046084492-0.9135103791.6012534291.1959370720.669249690.057439495
2221660.362880326-0.815408263-0.7384274363.44747191-2.012552587-1.231550435-1.834092487-1.236402035-2.603766291-1.3328970420.014907687-1.1502699361.28570619-0.226137147-0.127398935-1.942803888-0.748274770.556100374-0.8217994-2.054455120.181076981-0.3042142190.755070076
2231360.36811673-0.0405379521.347076680.4400532830.2538845790.9346075190.2115547621.1684690510.896705952-0.756836523-0.1304401110.4820232250.364875174-0.868181724-0.922403986-0.187956413-0.622771925-1.000011544-0.3535411780.8556378651.944980464-0.844285737-0.118789793
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11963 is not tested in classification assay
Integrated Annotations for CG11963 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
tricarboxylic acid cycleGO:0006099inferred from sequence or structural similarity with UniProtKB:Q9P2R7
regulation of centrosome duplication
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
succinate-CoA ligase complex (ADP-forming)GO:0009361inferred from sequence or structural similarity with EMBL:AF058953
succinate-CoA ligase complex (ADP-forming)
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
succinate-CoA ligase (ADP-forming) activityGO:0004775inferred from sequence or structural similarity with EMBL:AF058953
succinate-CoA ligase (ADP-forming) activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11963 in FlyBase
FLIGHTClick here to see CG11963 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11963 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11963
Entrez GeneEntrez Gene page for CG11963
UniprotUniprot page for CG11963

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)