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Gene Page - CG Number : CG11979
Gene Summary - CG11979:

CG11979: The gene Rpb5 is referred to in FlyBase by the symbol Dmel\Rpb5 (CG11979, FBgn0033571). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed RNA polymerase activity. There is experimental evidence that it is involved in the biological process: mitotic cell cycle G2/M transition DNA damage checkpoint. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: DNA-directed RNA polymerase, RPB5 subunit; RNA polymerase, Rpb5, N-terminal; RNA polymerase, subunit H/Rpb5 C-terminal; RNA polymerase, subunit H/Rpb5, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11979 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11979:CG11979 is perturbed in following parameters in primary screen: Tclc Tint2 Tint3 Tmph2
CG11979 is not tested in classification assay (fluid).
CG11979 is perturbed in following parameters in classification assay (transferrin): Fclc- Fint2- Fint3- Fmph1- Fmph2- Fmph3- Fnum- Okt-(tfr) Tclc- Tint2- Tint3- Tmph1- Tmph2- Tmph3- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11979.
Cell Count:
CG_NumberCategoryR1R2R3
CG11979Primary screen144247389
CG11979Secondary assay93312241053
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11979:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
221380.4706330070.4438393110.749019403-0.097762508-1.241703881-0.4171975611.885121387-0.324325411-1.1502657890.067054488-1.048580131-1.428017746-1.225228529-1.4136336361.28268386-1.28545925-0.1964444761.254471748-1.382784981-0.0709921333.863040172-0.1596268522.53236804
2221882.036887121.0904457550.6097587110.677554474-0.7646512431.7770138953.0324641971.4935852662.8970376224.9473345424.610011292-0.2477478090.6232259930.2806330211.0322856780.3082844474.6422984456.6375910397.1899183443.1320571131.444074403-0.7937407990.442632943
223980.2611497940.2670569691.206541453-0.1913310530.7291722762.9512988421.9981132241.9852574684.3174967664.3198550671.9612245820.757720392.8760802272.77224080210.804159170.5783579810.5356470224.8234736531.5910445925.0850759290.8672039094.0004263411.952378831
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11979Slide2F0.2850.6731.0320.847
CG11979Slide2O0.0690.7350.8620.910
CG11979Slide2T0.0030.6410.6530.643
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11979 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
transcription from RNA polymerase II promoterGO:0006366inferred from sequence or structural similarity with HGNC_gene:POLR2E; HGNC:9192; OMIM:180664 AND inferred from sequence or structural similarity with SGD_LOCUS:RPB5; SGD:S0000358
mitotic cell cycle G2/M transition DNA damage checkpoint
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
DNA-directed RNA polymerase II, core complexGO:0005665inferred from sequence or structural similarity with HGNC_gene:POLR2E; HGNC:9192; OMIM:180664 AND inferred from sequence or structural similarity with SGD_LOCUS:RPB5; SGD:S0000358
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA-directed RNA polymerase activityGO:0003899inferred from sequence or structural similarity with HGNC_gene:POLR2E; HGNC:9192; OMIM:180664 AND inferred from sequence or structural similarity with SGD_LOCUS:RPB5; SGD:S0000358
DNA binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG11979 in FlyBase
FLIGHTClick here to see CG11979 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11979 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11979
Entrez GeneEntrez Gene page for CG11979
UniprotUniprot page for CG11979

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)