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Gene Page - CG Number : CG11981
Gene Summary - CG11981:

CG11981: The gene Proteasome ╬▓3 subunit is referred to in FlyBase by the symbol Dmel\Pros╬▓3 (CG11981, FBgn0026380). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus; neurogenesis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteasome B-type subunit; Proteasome, beta-type subunit, conserved site; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in stages of adults of both sexes.

Gene summary for CG11981 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11981:CG11981 is perturbed in following parameters in primary screen: Fclc Fint1 Fint2 Fint3 Fint4 Fmph1 Fmph2 Fmph3 Okt Tclc Tint1 Tint2 Tint3 Tmph1 Tmph2 Tmph3
CG11981 is perturbed in following parameters in classification assay (fluid): LP_Fclc- NuCirc+(fld) Rto1- SP_Fclc- SP_Fint1- SP_Fint2-
CG11981 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fint1- Fint2- Fint4- Fmph1- Fmph2- Fmph3- Fnum- NuCellD+(tfr) NuSize-(tfr) Rto1-(tfr) Tclc- Tint1- Tmph1- Tmph2- Tmph3-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11981.
Cell Count:
CG_NumberCategoryR1R2R3
CG11981Primary screen48317261
CG11981Secondary assay126611861105
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11981:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22140-0.6032879132.619948373.6670687252.08748002-1.7986553271.9095051392.7003692832.188955749-2.7812704846.088979337-0.9526306260.72280464-1.6794092810.0815430136.231166086-2.352115741-1.2237937310.971912566-1.723946046-1.402169463-0.005277283-0.7534789330.389245907
22218614.8053546612.250392466.7777053624.380059492.71669614712.4774977510.4383698515.9680859515.0277592711.704349038.4618058739.0068068359.0440321626.9375424584.5118723833.36724142712.1848215710.8097818719.5763138810.73875502-0.2668580691.6859518460.296054347
223968.108321758.202370128.8804002443.0306503113.3256863117.388384246.1903800079.0890218810.23275975.9963963592.2935808620.8329620590.59465022-0.4049109638.097882951-0.4491663713.9600508626.6348808313.4183321658.004996668-0.7850561251.302720485-0.841713188
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11981Slide11C0.6651.0431.3240.847
CG11981Slide11O0.7040.9681.1300.761
CG11981Slide11P0.1250.8030.9090.863
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11981Slide2F0.0000.6410.6380.668
CG11981Slide2O0.1141.0501.1541.055
CG11981Slide2T0.1500.8520.8570.489
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG11981 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
proteolysisGO:0006508non-traceable author statement
response to DNA damage stimulus
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
proteasome core complexGO:0005839inferred from sequence or structural similarity with EMBL:AF058707
proteasome complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
endopeptidase activityGO:0004175inferred from sequence or structural similarity with EMBL:AF058707
endopeptidase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11981 in FlyBase
FLIGHTClick here to see CG11981 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11981 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11981
Entrez GeneEntrez Gene page for CG11981
UniprotUniprot page for CG11981

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)