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Gene Page - CG Number : CG11988
Gene Summary - CG11988:

CG11988: The gene neuralized is referred to in FlyBase by the symbol Dmel\neur (CG11988, FBgn0002932). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ubiquitin-protein ligase activity. There is experimental evidence for 18 unique biological process terms, many of which group under: biological regulation; system development; sensory organ development; response to stimulus; regulation of developmental process; regulation of neurogenesis; cell fate commitment; single-organism behavior; post-embryonic organ morphogenesis; locomotory behavior; localization; neuromuscular process. 101 alleles are reported. The phenotypes of these alleles are annotated with 41 unique terms, many of which group under: organ system subdivision; organ system; adult segment; non-connected developing system; portion of tissue; external compound sense organ; adult; thoracic segment; sense organ; peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: NEUZ; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG11988 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11988:CG11988 is not perturbed in primary screen.
CG11988 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11988.
Cell Count:
CG_NumberCategoryR1R2R3
CG11988Primary screen329271235
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11988:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22144-0.03500284-0.1593523471.3871175850.5247306550.2451801231.3361380112.4892384441.0656511490.7758159370.5374302760.890249081-0.4616649820.2845477040.2485347570.012204985-0.354987253-0.1983601590.232351647-0.2587090911.073014035-0.512763666-0.5647399360.231615154
222182-0.697270321-0.2873297131.042200421.199197815-0.248635182-0.2547244710.432737232-1.141119652-0.0207450741.9739759670.7022940150.376852918-1.592309028-0.264416489-0.607974241-0.7076783020.3421943121.82123395-0.1153395140.663101469-0.3915391410.160673850.40824118
22392-0.3394393290.6738457620.947255926-0.416878639-0.2240375832.5394416521.2044444061.8740216551.3901276390.4489548880.4704192184.2142726981.4561292051.841832018-0.3308931-1.0250381670.1543045970.4794922161.8779713621.2248447552.404286835-0.101387792-0.559562227
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG11988 is not tested in classification assay
Integrated Annotations for CG11988 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
germ-line stem cell maintenanceGO:0030718inferred from mutant phenotype
ectoderm development
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from direct assay
cytoplasm
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
DNA bindingGO:0003677inferred from sequence or structural similarity
ubiquitin-protein ligase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG11988 in FlyBase
FLIGHTClick here to see CG11988 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11988 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11988
Entrez GeneEntrez Gene page for CG11988
UniprotUniprot page for CG11988

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)