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Gene Page - CG Number : CG11990
Gene Summary - CG11990:

CG11990: The gene hyrax is referred to in FlyBase by the symbol Dmel\hyx (CG11990, FBgn0037657). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; chaeta morphogenesis; positive regulation of smoothened signaling pathway; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway; imaginal disc-derived leg morphogenesis; compound eye morphogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: leg; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: RNA polymerase II accessory factor, Cdc73. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.

Gene summary for CG11990 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG11990:CG11990 is perturbed in following parameters in primary screen: Fmph2
CG11990 is perturbed in following parameters in classification assay (fluid): SP_Fclc- SP_Fint4-
CG11990 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG11990.
Cell Count:
CG_NumberCategoryR1R2R3
CG11990Primary screen43237097
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG11990:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22146-0.5934374810.8520191310.953212432-0.0487423220.0930952673.2800154215.8129252253.6408916181.9736449890.386898049-0.099430014-0.2271762040.7416738441.7165238791.5819914-0.0734796271.432079283-0.0177598290.6348962142.6030166530.1292249723.0773915372.414129465
2222100.5297601411.0803171182.3195375430.045001871-0.224777742.2766449233.934170851.4733788681.7342304150.5995877461.7621246660.2479599581.6469577930.717013790.334751246-0.4706703870.9426622530.6771678680.5505782962.555708244-0.2059883381.464292365-0.02304319
223120-0.046734936-0.973573498-0.847372494-0.742699785-2.397677126-2.817211835-1.171058964-1.904977883-4.37928801-0.620922879-1.219198552-0.874408361-1.648181392-1.1505965081.328817484-1.935311099-1.430803049-1.222060044-1.410427653-3.569464555-0.1901759570.2694590080.854076728
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG11990Slide26C0.1900.8350.9920.910
CG11990Slide26O0.6280.9481.1920.497
CG11990Slide26P0.1350.6220.8020.137
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG11990 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
positive regulation of smoothened signaling pathwayGO:0045880inferred from mutant phenotype inferred from genetic interaction with ptc inferred from genetic interaction with ci
positive regulation of transcription, DNA-dependent
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
protein complexGO:0043234inferred from physical interaction with ci
Cdc73/Paf1 complex
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
transcription factor bindingGO:0008134inferred from physical interaction with ci
Other annotations
DatabaseLink
FlyBaseClick here to see CG11990 in FlyBase
FLIGHTClick here to see CG11990 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG11990 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG11990
Entrez GeneEntrez Gene page for CG11990
UniprotUniprot page for CG11990

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)