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Gene Page - CG Number : CG12000
Gene Summary - CG12000:

CG12000: The gene Proteasome ╬▓7 subunit is referred to in FlyBase by the symbol Dmel\Pros╬▓7 (CG12000, FBgn0250746). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; mitotic spindle elongation; cell proliferation; cellular process; response to DNA damage stimulus; mitotic spindle organization; neurogenesis. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Proteasome B-type subunit; Proteasome endopeptidase complex, beta subunit; Proteasome, beta-type subunit, conserved site; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.

Gene summary for CG12000 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12000:CG12000 is perturbed in following parameters in primary screen: Fclc Fint1 Fint2 Fint3 Fmph1 Fmph2 Fmph3 Okt Rto3 Tclc Tint1 Tint2 Tint3 Tmph2 Tmph3
CG12000 is perturbed in following parameters in classification assay (fluid): CellSize-(fld) LP_Fint1+ LP_Fint2+ LP_Fint3+ LP_Fint4- NuCirc+(fld) NuFluct-(fld) NuSize-(fld) Rto1- SP_Fclc- SP_Fint4-
CG12000 is perturbed in following parameters in classification assay (transferrin): Fclc- Fint2- Fint3- Rto1-(tfr) Rto2-(tfr) Rto3-(tfr) Tint1- Tint2- Tint3- Tmph2- Tmph3-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12000.
Cell Count:
CG_NumberCategoryR1R2R3
CG12000Primary screen86280397
CG12000Secondary assay812631259
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12000:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22151-0.7470433970.9807959881.308375318-0.246444276-1.574284679-2.384295068-3.108934893-3.226835915-4.711806938-0.290390209-1.223521532-0.099263163-0.3759202996.1833516481.055862029-1.669947672-2.375961954-2.69962844-1.282314277-5.0619425141.3676407890.5846512010.840245115
2222059.7431545019.453031315.816969431.646540584-0.0682208273.4734667036.6793146283.8386054268.2843306427.027938912.777993240.613331670.150793253-0.2228911114.034694692.77028139511.8743072411.3059582817.803702186.33094175-0.2804226140.176822054-0.429230511
2231158.40547803311.902785911.444909433.5794426134.78492338810.012384477.7867709912.271832115.222994893.1862530760.4822723251.015361943.2637803634.15038413810.363012090.4808362462.2120763698.1972300194.22950244411.996234561.9970786210.575802515-0.225405807
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG12000Slide11C0.0811.4671.1921.163
CG12000Slide11O0.3031.3141.0141.063
CG12000Slide11P0.9731.2500.8380.927
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG12000Slide2F0.1410.8320.8760.531
CG12000Slide2O0.2730.9340.6860.976
CG12000Slide2T0.0020.5030.4610.277
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG12000 :Gene Ontology Annoations: Biological Process
Gene Ontology Annoations: Cellular Component
Gene Ontology Annoations: Molecular Function
Other annotations
DatabaseLink
FlyBaseClick here to see CG12000 in FlyBase
FLIGHTClick here to see CG12000 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12000 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12000
Entrez GeneEntrez Gene page for CG12000
UniprotUniprot page for CG12000

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)