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Gene Page - CG Number : CG12008
Gene Summary - CG12008:

CG12008: The gene karst is referred to in FlyBase by the symbol Dmel\kst (CG12008, FBgn0004167). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding; microtubule binding. There is experimental evidence that it is involved in the biological process: endocytosis; wound healing; cytokinesis. 24 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; organ system subdivision; external compound sense organ; portion of tissue; adult; peripheral nervous system; epithelial cell; adult segment; gut section; histaminergic neuron. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Actinin-type, actin-binding, conserved site; Calponin homology domain; Pleckstrin homology domain; Pleckstrin homology domain, spectrin-type; Pleckstrin homology-like domain; Spectrin repeat; Spectrin/alpha-actinin; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages.

Gene summary for CG12008 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12008:CG12008 is not perturbed in primary screen.
CG12008 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12008.
Cell Count:
CG_NumberCategoryR1R2R3
CG12008Primary screen232142271
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12008:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22156-0.389285709-0.222440984-0.2163757051.1966301690.712386341.1323555741.1395636650.7913334081.3811381732.1565415042.167598124-0.5276770031.4896218921.814388859-0.2742658142.010157841.7719890971.8165996431.5993979991.4003906371.347345983-0.2528265120.561292027
222200-0.441693621-0.369337319-0.7198275840.190473873-3.510553147-1.937717226-1.298445501-2.17671152-3.126919645-0.112055354-0.9639735070.6502301090.1152288150.0490178140.035743575-2.402659426-1.707851901-0.3502208-1.999433652-2.7106982120.353364232-0.217233506-0.316091782
2231100.809830153-0.483360381-0.4454223711.6309559341.2395933041.0942222920.7969517341.5961326171.7112155750.525191491.382861515-0.451044390.8634193331.6323979960.2217107161.5522109520.8860322020.9064394091.3974901361.594996795-0.1323399240.2415443752.429187173
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG12008 is not tested in classification assay
Integrated Annotations for CG12008 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
zonula adherens assemblyGO:0045186traceable author statement
cytokinesis
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
spectrinGO:0008091inferred from sequence or structural similarity
apicolateral plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
cytoskeletal protein bindingGO:0008092inferred from sequence or structural similarity
actin binding
Other annotations
DatabaseLink
FlyBaseClick here to see CG12008 in FlyBase
FLIGHTClick here to see CG12008 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12008 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12008
Entrez GeneEntrez Gene page for CG12008
UniprotUniprot page for CG12008

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)