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Gene Page - CG Number : CG12021
Gene Summary - CG12021:

CG12021: The gene Patj is referred to in FlyBase by the symbol Dmel\Patj (CG12021, FBgn0067864). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: myosin II light chain binding; protein kinase C binding. There is experimental evidence that it is involved in the biological process: adherens junction organization; pupal development; adherens junction maintenance; morphogenesis of follicular epithelium; establishment or maintenance of polarity of follicular epithelium; establishment of planar polarity; establishment or maintenance of apical/basal cell polarity; negative regulation of myosin-light-chain-phosphatase activity; photoreceptor cell maintenance; photoreceptor cell morphogenesis. 37 alleles are reported. The phenotypes of these alleles are annotated with: pupa; embryonic/first instar larval cuticle; pupal thorax; ectoderm; imaginal disc. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: L27; PDZ domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG12021 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12021:CG12021 is perturbed in following parameters in primary screen: Fmph2
CG12021 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) NuCirc-(fld) NuFluct+(fld) NuSize+(fld)
CG12021 is not tested in classification assay (transferrin).
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12021.
Cell Count:
CG12021Primary screen198337193
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12021:
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse

Integrated Annotations for CG12021 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
establishment of planar polarityGO:0001736inferred from mutant phenotype
cell-cell junction assembly
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
apical plasma membraneGO:0016324non-traceable author statement
septate junction
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein kinase C bindingGO:0005080inferred from physical interaction with aPKC
Other annotations
FlyBaseClick here to see CG12021 in FlyBase
FLIGHTClick here to see CG12021 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12021 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12021
Entrez GeneEntrez Gene page for CG12021
UniprotUniprot page for CG12021

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)