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Gene Page - CG Number : CG12028
Gene Summary - CG12028:

CG12028: The gene disembodied is referred to in FlyBase by the symbol Dmel\dib (CG12028, FBgn0000449). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ecdysteroid 22-hydroxylase activity. There is experimental evidence that it is involved in the biological process: central nervous system development; dorsal closure; ecdysone biosynthetic process; head involution; midgut development; chitin-based embryonic cuticle biosynthetic process. 25 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: organ system; multicellular structure; cuticle; organ system subdivision; nervous system; primordium; non-connected developing system; integumentary system; multi-cell-component structure; presumptive embryonic/larval nervous system; ectoderm derivative; cytoplasmic part; cephalopharyngeal skeleton; commissure; midgut constriction. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages.

Gene summary for CG12028 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12028:CG12028 is not perturbed in primary screen.
CG12028 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12028.
Cell Count:
CG_NumberCategoryR1R2R3
CG12028Primary screen345204267
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12028:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22168-0.169643199-0.4252265730.4531937040.2049185221.2908632451.2652862520.7790246191.2032960151.5548512550.1944877410.931154801-0.4847748230.7126216461.20998064-0.5070381271.5796706681.703285231.192117141.7912832321.3474994551.029789598-0.3440874891.021176245
2222182.9177115261.7618236770.6289980051.2057841660.2392239110.6256613311.4119486370.6694576180.662101920.197805920.8297963680.4241080991.6717977841.476078079-0.3260245021.3527550720.4620375471.8155351830.75871260.837260720.482003071-0.608076512-0.194440588
22368-0.8754566290.204946841-0.335511874-0.3652719621.3113512251.4459197113.642235061.9194857322.5535200190.3870092730.883020421-0.1365307851.9259449011.746167977-0.3928375072.0735393252.2474219131.2207824531.933380612.9139684511.3230406722.7014343092.049336014
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG12028 is not tested in classification assay
Integrated Annotations for CG12028 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
dorsal closureGO:0007391inferred from mutant phenotype
ecdysone biosynthetic process
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
mitochondrionGO:0005739inferred from sequence or structural similarity
mitochondrial inner membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
electron carrier activityGO:0009055non-traceable author statement
electron carrier activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG12028 in FlyBase
FLIGHTClick here to see CG12028 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12028 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12028
Entrez GeneEntrez Gene page for CG12028
UniprotUniprot page for CG12028

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)