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Gene Page - CG Number : CG12072
Gene Summary - CG12072:

CG12072: The gene warts is referred to in FlyBase by the symbol Dmel\wts (CG12072, FBgn0011739). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; sensory organ development; regulation of developmental process; regulation of neurogenesis; cell proliferation; response to ionizing radiation; growth; cell cycle; regulation of cell morphogenesis; stem cell proliferation; cell cycle process; developmental growth; regulation of apoptotic process; trachea morphogenesis; neuron differentiation. 113 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system subdivision; external compound sense organ; organ system; peripheral nervous system; imaginal precursor; adult segment; embryonic/larval imaginal precursor; cell part; late extended germ band embryo; histaminergic neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: AGC-kinase, C-terminal; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual-specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.

Gene summary for CG12072 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12072:CG12072 is perturbed in following parameters in primary screen: Fint1 Fmph2
CG12072 is perturbed in following parameters in classification assay (fluid): CellSize+(fld) NuCirc-(fld) NuFluct+(fld) NuSize+(fld) Rto2- Rto3- SP_Fnum-
CG12072 is perturbed in following parameters in classification assay (transferrin): CellSize-(tfr) Fclc- Fint3- Fint4- NuCellD+(tfr) Okt+(tfr) Rto2-(tfr) Tint4- Tnum-
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12072.
Cell Count:
CG_NumberCategoryR1R2R3
CG12072Primary screen80222232
CG12072Secondary assay5679131048
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12072:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22192-1.109132755-0.413593873-0.114989714-0.635025377-3.991871084-6.23479716-4.322211992-6.855651024-3.669393644-0.026579546-1.708911973-0.330640072-1.125879023-1.080256655-0.575974828-2.103925972-1.584216967-2.322885422-2.43293631-3.540972864-1.186275245-0.1897294192.88144185
2221348.5544796779.5802395695.302439152-0.8724304810.477227061.7728787343.0611032161.1871143090.81635374-0.798315055-0.8052445211.858415845-1.09143517-1.081036954-0.61825073-0.5649675-0.936575343-0.450590886-1.018413610.968082036-0.0391483232.1742598720.296507987
223445.1913815692.1199138552.133169944-0.7162573896.5318918763.7312416637.9579979484.0274631922.7892363411.6860389440.7947495980.6984164413.5159308292.1684949-0.2156136371.5866267081.4561865441.8203144471.5885732613.097781594-0.288489421.875389183-0.684378079
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):Fluid:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG12072Slide21C0.3201.1121.0761.046
CG12072Slide21O0.1100.3420.4240.474
CG12072Slide21P0.2030.9350.8620.820
C=Fdex Chase; O=Surface TfR (Okt9); P=Fdex Pulse


Transferrin:
CG_NumberSlide No.ttest P-valueRatio 1Ratio 2Ratio 3
CG12072Slide13F0.3380.8661.0110.962
CG12072Slide13O0.0021.1691.1421.206
CG12072Slide13T0.0220.5800.7470.787
F=Fdex; O=Surface TfR (Okt9); T=Tf

Integrated Annotations for CG12072 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
terminal branching, open tracheal systemGO:0007430non-traceable author statement
imaginal disc growth
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
-
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
protein serine/threonine kinase activityGO:0004674inferred from sequence or structural similarity
protein serine/threonine kinase activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG12072 in FlyBase
FLIGHTClick here to see CG12072 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12072 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12072
Entrez GeneEntrez Gene page for CG12072
UniprotUniprot page for CG12072

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)