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Gene Page - CG Number : CG12073
Gene Summary - CG12073:

CG12073: The gene Serotonin receptor 7 is referred to in FlyBase by the symbol Dmel\5-HT7 (CG12073, FBgn0004573). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity. There is experimental evidence that it is involved in the biological process: male courtship behavior, proboscis-mediated licking; female mating behavior; male mating behavior; courtship behavior; male courtship behavior, orientation prior to leg tapping and wing vibration; male courtship behavior, veined wing vibration. 11 alleles are reported. The phenotype of these alleles is annotated with: Malpighian tubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dopamine receptor; GPCR, rhodopsin-like; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.

Gene summary for CG12073 is obtained from FlyBase (FB2013_01, released January 23rd, 2013)
Experimental Summary - CG12073:CG12073 is not perturbed in primary screen.
CG12073 is not tested in classification assay.
Cellular phenotyping(Images): Click here to access phenotyping images of gene CG12073.
Cell Count:
CG_NumberCategoryR1R2R3
CG12073Primary screen254170161
R1: Replicate No. 1; R2: Replicate No.2; R3: Replicate No. 3
Primary screen data - CG12073:
SNRNWNFint1Fint2Fint3Fint4FnumFmph1Fmph2Fmph3FclcTint1Tint2Tint3Tint4Rto1Rto2Rto3OktTnumTmph1Tmph2Tmph3TclcCellSize
22193-0.434949901-0.159960181-0.3370712980.3311057270.3521211760.359719641-0.086462163-0.0312590330.9170113440.0199517950.8577565-0.0645355620.6960383740.6662230920.0616725810.9519840391.4184608090.3968582881.3269796451.0937950590.572176654-0.101442983-0.49151228
222253-0.428534288-0.4381981240.193132796-0.456966433-0.2595071610.1255226460.7325243960.271370065-0.2907779510.132372327-1.2017636460.42851724-2.043994932-2.657232203-0.310462675-1.400825653-1.003340665-0.914219723-0.746269687-0.2470319180.653000615-0.61101069-0.562329031
223432.5461429092.042735364-0.6642631740.964238245-0.2154674280.4627067723.7870621660.191890989-0.406277043-1.329804295-0.613314184-0.463971379-1.374476691-1.404777833-0.286300113-0.282845513-1.131398185-0.582154078-1.2281953520.281559103-0.348381294-0.714418353.583899538
SN: Slide Number; RN: Replicate Number; WN: Well Number
Experimental Data (Classification Assay):CG12073 is not tested in classification assay
Integrated Annotations for CG12073 :Gene Ontology Annoations: Biological Process
Biological Process - TermGO IDEvidence
activation of adenylate cyclase activity by serotonin receptor signaling pathwayGO:0007192traceable author statement
serotonin receptor signaling pathway
Gene Ontology Annoations: Cellular Component
Cellular Component - TermGO IDEvidence
plasma membraneGO:0005886inferred from sequence or structural similarity with MGD:Htr2c; MGI:MGI:96281
integral to plasma membrane
Gene Ontology Annoations: Molecular Function
Molecular Function - TermGO IDEvidence
serotonin receptor activityGO:0004993traceable author statement
serotonin receptor activity
Other annotations
DatabaseLink
FlyBaseClick here to see CG12073 in FlyBase
FLIGHTClick here to see CG12073 in FLIGHT(Compendium of Drosophila in vivo and in vitro RNAi screens)
BioGRIDClick here to see CG12073 in BioGRID (Interaction Summary)
Off-targetClick here for Off-target data for CG12073
Entrez GeneEntrez Gene page for CG12073
UniprotUniprot page for CG12073

Endosite Team :
Prof. Satyajit Mayor (Contact : mayor@ancbs.res.in)
Prof. R. Sowdhamini (Contact : mini@ncbs.res.in)